Reaction rates of superoxide radicals with the essential amino acids
Upper limits for the rates of reaction of amino acids with superoxide radicals have been determined spectrophotometrically by the stopped flow method. Rate measurements at 23/sup 0/C for the reaction of HO/sub 2/ with amino acids were carried out in the pH range between 1 and 2; similar measurements for O/sub 2//sup -/ were taken near pH 10. The results show that overall amino acids are relatively unreactive toward both HO/sub 2/ and O/sup -//sub 2/. Computed second order rate constants for their interaction with HO/sub 2/ range from 10 dm/sup 3/ mol/sup -1/ s/sup -1/ for aliphatic amino acids to about 600 dm/sup 3/ mol/sup -1/ s/sup -1/. The second order rate constants for the interaction of amino acids with O/sup -//sub 2/ are smaller and range from 0.1 to approximately 20 dm/sup 3/ mol/sup -1/ s/sup -1/.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- EY-76-C-02-0016
- OSTI ID:
- 6745137
- Report Number(s):
- BNL-24401; CONF-780647-1
- Country of Publication:
- United States
- Language:
- English
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