Management of cancer during pregnancy
Journal Article
·
· Arch. Intern. Med.; (United States)
Although cancer during pregnancy is infrequent, its management is difficult for patients, their families, and their physicians. When termination of the pregnancy is unacceptable, decisions regarding the use of irradiation and chemotherapy are complicated by the well-known high risks of abortion and fetal malformation. This risk is concentrated in the first trimester and varies with the choice of chemotherapeutic agents or combinations of agents. There is only minimal evidence of increased risk of malformation or abortion in the second or third trimester. Recent progress in cancer therapy has made cure a reasonable goal, and for some malignant neoplasms, cure is still possible even when initial therapy is modified or delayed. When cure is a reasonable goal, curative therapy should not be compromised by modification or delay. When treatment for cure or significant palliation is not possible, however, the goal should shift to protection of the fetus from damage by the injudicious use of teratogenic cancer therapy. This report will review the available data that may assist in these difficult decisions. 114 references.
- Research Organization:
- Harry S Truman Memorial Veterans Hospital, Columbia, MO (USA)
- OSTI ID:
- 6745035
- Journal Information:
- Arch. Intern. Med.; (United States), Journal Name: Arch. Intern. Med.; (United States) Vol. 148:9; ISSN AIMDA
- Country of Publication:
- United States
- Language:
- English
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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOCUMENT TYPES
DOSES
FETUSES
INJURIES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PREGNANCY
PRENATAL EXPOSURE
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
REVIEWS
RISK ASSESSMENT
SIDE EFFECTS
THERAPY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
DOCUMENT TYPES
DOSES
FETUSES
INJURIES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PREGNANCY
PRENATAL EXPOSURE
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
REVIEWS
RISK ASSESSMENT
SIDE EFFECTS
THERAPY