Relationship between bronchiolar dose and lung carcinoma induction following inhalation of /sup 239/PuO/sub 2/ in rats
Conference
·
OSTI ID:6744701
This manuscript describes preliminary observations in a lifespan and serial sacrifice study with 3332 female, Wistar rats exposed to high-fired /sup 239/PuO/sub 2/ aerosols. Sufficient numbers of sham-control and low dose (equivalent to maximal permissible occupational lung deposition of 0.6 kBq in standard man) animals are provided to statistically estimate lung cancer risk and define the cellular-microdosimetric relationships leading to lung tumor formation. Whole-body counting for /sup 169/Yb tagged /sup 239/PuO/sub 2/ aerosol provided a very accurate method for determining Pu ILB in individual rats (Sanders et al., 1986). The experimental design, methodology and early results of the lifespan study have been previously reported (Sanders et al., 1986, 1988a). 7 refs., 3 figs.
- Research Organization:
- Pacific Northwest Lab., Richland, WA (USA)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6744701
- Report Number(s):
- PNL-SA-15710; CONF-8809137-2; ON: DE89001474
- Country of Publication:
- United States
- Language:
- English
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Sat Oct 01 00:00:00 EDT 1988
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Related Subjects
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ANIMALS
BODY
CARCINOGENESIS
CARCINOMAS
CHALCOGENIDES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EVEN-ODD NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
MORTALITY
NEOPLASMS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PLUTONIUM COMPOUNDS
PLUTONIUM OXIDES
RADIOINDUCTION
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RESPIRATORY SYSTEM
RISK ASSESSMENT
RODENTS
SEX DEPENDENCE
SURVIVAL TIME
TRACER TECHNIQUES
TRANSURANIUM COMPOUNDS
VERTEBRATES
YTTERBIUM 161
YTTERBIUM ISOTOPES
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ANIMALS
BODY
CARCINOGENESIS
CARCINOMAS
CHALCOGENIDES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EVEN-ODD NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
MORTALITY
NEOPLASMS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PLUTONIUM COMPOUNDS
PLUTONIUM OXIDES
RADIOINDUCTION
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RESPIRATORY SYSTEM
RISK ASSESSMENT
RODENTS
SEX DEPENDENCE
SURVIVAL TIME
TRACER TECHNIQUES
TRANSURANIUM COMPOUNDS
VERTEBRATES
YTTERBIUM 161
YTTERBIUM ISOTOPES