Morphometric study of rat and hamster lung following inhalation of /sup 239/PuO/sub 2/

Journal Article · Sun Nov 01 04:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575659· OSTI ID:5887272

Rhoads, K; Mahaffey, J A; Sanders, C L

Wistar rats and Syrian Golden hamsters inhaled /sup 239/PuO/sub 2/, at doses near those for maximum lung tumor response in rats. Mean (+-SD) lung doses were 600 +- 290 rad for rats and 910 +- 840 rad for hamsters surviving from 120 to 350 days. Morphometric analyses were performed on light and electron micrographs of lung. Inhaled /sup 239/Pu/sub 2/ had little effect on the overall structure or composition of lung at times up to 350 days after exposure. A number of species differences were noted. It was concluded that different tissue responses of the lung parenchyma could not explain differences in lung tumor formation between rats and hamsters following inhalation of /sup 239/PuO/sub 2/.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5887272
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 88:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CHALCOGENIDES
DISEASES
DOSES
EVEN-ODD NUCLEI
HAMSTERS
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
MAMMALS
MORPHOLOGICAL CHANGES
NEOPLASMS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PLUTONIUM 239
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES