In vitro studies on interaction of mercuric mercury and selenite in rabbit blood
The behaviors of inorganic mercury and selenite in rabbit blood, added in vitro individually or in combination, were investigated. Inorganic mercury incorporated into erythrocyte in the absence of selenite was mainly present in the fractions which were eluted from Sephadex G-200 column just after hemoglobin. On the other hand selenium incorporated into erythrocyte in the absence of mercury was eluted in hemoglobin fractions and also in those which are almost completely retained by the column. In the combination experiment, however, the incorporation of mercury and selenium was remarkably enhanced and the increased amounts of both the compounds were eluted together with each other around the void volume region of the Sephadex G-200 column. The existing state of mercury and selenium in the high-molecular weight fractions and the effects of some metabolic inhibitors on the behavior of these compounds in blood were also studied.
- Research Organization:
- Kitasato Univ., Tokyo
- OSTI ID:
- 6743932
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 20:1; ISSN RCOCB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHROMATOGRAPHY
ELEMENTS
ERYTHROCYTES
GLOBIN
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IN VITRO
MAMMALS
MERCURY
METALS
MOLECULAR WEIGHT
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RABBITS
SELENIUM
SEMIMETALS
SEPARATION PROCESSES
VERTEBRATES