Inhibition of hematopoietic recovery from radiation-induced myelosuppression by natural killer cells

Journal Article · Tue May 01 04:00:00 EDT 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577602· OSTI ID:6743172

Pantel, K; Boertman, J; Nakeff, A ^[1]

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1. Wayne State Univ. School of Medicine, Detroit, MI (USA)

We have examined the role of natural killer (NK) cells in situ in the recovery of marrow hematopoiesis in B6D2F1 mice receiving various doses of total-body irradiation (TBI) as a well-characterized model for treatment-induced myelosuppression. Applying an in situ cytotoxic approach for ablating NK 1.1 cells, we have demonstrated that NK 1.1 cells differentially inhibit the recovery of hematopoietic stem cells (CFU-S) and their progenitor cells committed to granulocyte-macrophage differentiation from a sublethal dose of TBI (9 Gy) while not affecting the recovery of progenitor cells committed to either erythroid or megakaryocyte differentiation from TBI. However, recoveries of CFU-S and progenitor cells were unaffected by the ablation of NK cells prior to a moderate dose of TBI (2 Gy). These findings provide in situ evidence that NK cells are potential inhibitors of hematopoietic recovery from treatment-induced myelosuppression.

• OSTI ID: 6743172
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 122:2; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL DIFFERENTIATION
CONNECTIVE TISSUE CELLS
DISEASES
EXTERNAL IRRADIATION
FUNCTIONS
IMMUNE SYSTEM DISEASES
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MACROPHAGES
MAMMALS
MATERIALS
MICE
PHAGOCYTES
RADIATION EFFECTS
RADIOINDUCTION
RECOVERY
RODENTS
SOMATIC CELLS
STEM CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION