/sup 99/Mo metabolism in sheep after the intravenous injection of (/sup 99/Mo) thiomolybdates
Journal Article
·
· J. Inorg. Biochem.; (United States)
(/sup 99/Mo)di-, tri-, and tetrathiomolybdate (5.4 to 62.5 mg of Mo) were given by intravenous injection to sheep maintained on a sulfur-supplemented (3 g of S/kg) diet. All the compounds were metabolized very rapidly over the first 15 min postinjection, but relatively slowly thereafter, with a t1/2 of about 30 hr for dithiomolybdate and 40 h for tri- and tetrathiomolybdate. The (/sup 99/Mo) metabolites present in plasma were identified by Sephadex G-25 chromatography. The main fate of the compounds injected appeared to be stepwise transformation to molybdate and subsequent rapid urinary elimination. Over 90-100 hr more than 90% of the radioactivity was excreted in urine, compared to less than 5% in the feces. The trichloroacetic acid (TCA) solubility of plasma copper and the diamine oxidase activity of ceruloplasmin was depressed, particularly over the first 15 min postinjection and a more persistant TCA-insoluble Cu fraction was apparent.
- Research Organization:
- Univ. of Dublin, Ireland
- OSTI ID:
- 6742938
- Journal Information:
- J. Inorg. Biochem.; (United States), Journal Name: J. Inorg. Biochem.; (United States) Vol. 19:2; ISSN JIBID
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of /sup 67/Cu and /sup 99/Mo labeled tetrathiomolybdate on the distribution of /sup 67/Cu, Cu, and /sup 99/Mo in bile fractions in sheep
Enterohepatic recirculation of trichloroethanol glucuronide as a significant source of trichloroacetic acid. Metabolites of trichloroethylene.
VISUALIZATION OF THE LIVER BY SCANNING WITH Mo$sup 99$ (MOLYBDATE) AS TRACER
Journal Article
·
Fri Mar 31 23:00:00 EST 1989
· J. Inorg. Biochem.; (United States)
·
OSTI ID:6071878
Enterohepatic recirculation of trichloroethanol glucuronide as a significant source of trichloroacetic acid. Metabolites of trichloroethylene.
Journal Article
·
Thu May 01 00:00:00 EDT 1997
· Drug Metabolism and Disposition
·
OSTI ID:1728618
VISUALIZATION OF THE LIVER BY SCANNING WITH Mo$sup 99$ (MOLYBDATE) AS TRACER
Journal Article
·
Thu Aug 01 00:00:00 EDT 1963
· Journal of Laboratory and Clinical Medicine (U.S.)
·
OSTI ID:4685400
Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DIET
DOMESTIC ANIMALS
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METABOLISM
MOLYBDATES
MOLYBDENUM 99
MOLYBDENUM COMPOUNDS
MOLYBDENUM ISOTOPES
NONMETALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
RADIOISOTOPES
RUMINANTS
SHEEP
SULFUR
THIOLS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DIET
DOMESTIC ANIMALS
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METABOLISM
MOLYBDATES
MOLYBDENUM 99
MOLYBDENUM COMPOUNDS
MOLYBDENUM ISOTOPES
NONMETALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
RADIOISOTOPES
RUMINANTS
SHEEP
SULFUR
THIOLS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES