Vasomotion of renal blood flow in essential hypertension. Oscillations in xenon transit

Journal Article · · Hypertension (Dallas); (United States)

DOI:https://doi.org/10.1161/01.HYP.6.4.579· OSTI ID:6741113

Hollenberg, N K; Sandor, T

To assess the frequency and magnitude of phasic renal blood flow changes in essential hypertension, we applied an analytical method based on the estimation of power spectral density to xenon transit through the kidney. Despite similar age and gender distribution of the patients and exclusion of those with accelerated hypertension, mean renal blood flow was significantly lower in 100 patients with essential hypertension (299 +/- 8 ml/100 g/min) than in the 144 normal subjects (335 +/- 6 ml/100 g/min; p less than 0.001). Normalized power, the index of oscillatory behavior, was more than twice normal in patients with essential hypertension (p less than 0.001), but there was no difference in the frequency or cycle length of the oscillation. Two maneuvers that induced renal vasoconstriction, the application of cuffs to the thighs which were then inflated to diastolic blood pressure and an emotional provocation, reduced renal blood flow much more in patients with essential hypertension (p less than 0.01) in association with a striking increase in normalized power (p less than 0.001). The oscillations, which reflected not the phasic blood pressure change but rather the phasic change in renal perfusion, provided additional evidence that renal vasoconstriction plays an active role in the pathogenesis of essential hypertension.

• Research Organization: Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts
• OSTI ID: 6741113
• Journal Information: Hypertension (Dallas); (United States), Journal Name: Hypertension (Dallas); (United States) Vol. 6:4; ISSN HPRTD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
BLOOD PRESSURE
BODY
CARDIOVASCULAR DISEASES
DISEASES
ELEMENTS
FLUIDS
GASES
HYPERTENSION
ISOTOPE APPLICATIONS
KIDNEYS
NONMETALS
ORGANS
PATHOGENESIS
PATIENTS
RARE GASES
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
XENON