Testing for nondisjunction in the mouse. [X-rays]

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.7931123· OSTI ID:6739208

Chandley, A C; Speed, R M

Tests for nondisjunction have been carried out in male and female mice. Ten-day fetal progeny of control and treated adults have been karyotyped to establish spontaneous and induced levels of aneuploidy. In males, the effects of 100 rad x-rays on type A spermatogonia and early primary spermatocytes, and the effects of Mitomycin C (2 mg/kg) on early primary spermatocytes, have been tested. The results show insensitivity of primary spermatocytes to both agents, but a 3.5-fold increase in nondisjunction following spermatogonial irradiation. In females, comparisons have been made between young controls, young x-rayed (5 rad), aged controls and aged x-rayed (5 rad) animals. The ageing effect on nondisjunction is observed, but too few fetuses have been analyzed to reach conclusions regarding enhancement of nondisjunction levels by low doses of x-rays.

• Research Organization: Western General Hospital, Edinburgh, Scotland
• OSTI ID: 6739208
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 31; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANEUPLOIDY
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DRUGS
ELECTROMAGNETIC RADIATION
FEMALES
FETUSES
GAMETES
GERM CELLS
IONIZING RADIATIONS
IRRADIATION
KARYOTYPE
LOW DOSE IRRADIATION
MALES
MAMMALS
MICE
MITOMYCIN
NON-DISJUNCTION
PLOIDY
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SIDE EFFECTS
SPERMATOCYTES
SPERMATOGONIA
VERTEBRATES
X RADIATION