Increased vascular response to adrenergic stimulation in rats exposed to cadmium

Journal Article · Sat Jul 01 04:00:00 EDT 1978 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397809529679· OSTI ID:6736342

Nechay, B R; Williams, B J; Steinsland, O S; Hall, C E

Adult female rats were injected ip with a low total dose (1 to 2.25 mg/kg) or a high total dose (7.5 mg/kg) of cadmium, as cadmium chloride with cysteine, given in divided doses spaced over 1 to 3 wk. At 1 to 4 wk after administration of high doses of cadmium, anesthetized rats were less responsive to the pressor effect of norepinephrine (1.0 to 10.0 ..mu..g/kg, iv) than were controls. This type of effect has been described previously by other investigators and was not explored further in this study. In contrast to the results in high-cadmium animals, anesthetized rats of the low-cadmium group, tested 1 to 4 wk after exposure, were more sensitive to the pressor effects of norepinephrine (0.1 to 10.0 ..mu..g/kg, iv) than were controls. This increase in sensitivity was no longer apparent in animals tested 16 to 26 wk later. Neither basal blood pressure in anesthetized animals nor systolic pressure in conscious animals of the low-cadmium series was different from the corresponding value in controls. Aortic rings isolated from low-cadmium animals 1 to 4 wk after cadmium exposure developed more tension in the presence of norepinephrine (10/sup -9/ to 10/sup -7/ M) than did similar preparations obtained from control rats. Tail arteries isolated from low-cadmium animals 1 to 4 wk after exposure exhibited a greater pressor response to periarterial sympathetic nerve stimulation than did arteries from control rats. It is concluded that cadmium can affect the vascular response to norepinephrine without altering basal blood pressure, and that the direction of the effect is dependent on the level of exposure.

• Research Organization: Univ. of Texas, Galveston
• OSTI ID: 6736342
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 4:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ADULTS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD VESSELS
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELEMENTS
FEMALES
HALIDES
HALOGEN COMPOUNDS
HORMONES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
METALS
NORADRENALINE
PHYSIOLOGY
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TOXICITY
VASOCONSTRICTION
VERTEBRATES