Successful imaging of human cancer with indium-111-labeled phospholipid vesicles

Journal Article · Thu Sep 01 00:00:00 EDT 1988 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19880901)62:5<905::AID-CNCR2820620509>3.0.CO;2-3· OSTI ID:6735492

Presant, C A; Proffitt, R T; Turner, A F; Williams, L E; Winsor, D; Werner, J L; Kennedy, P; Wiseman, C; Gala, K; McKenna, R J

Twenty-four patients with proven primary and/or metastatic cancer received single intravenous injections of phospholipid vesicles containing 0.5 mCi of Indium-111. Gamma camera scintigraphy 1 to 72 hours later visualized tumors in 22 patients (92%), including carcinomas of breast, lung, colon, prostate, kidney, cervix, thyroid, and soft tissue sarcoma, lymphoma, and melanoma. Tumor sites that were identified included soft tissues, bone, lung, liver, lymph node, and spinal cord. There were only two false-positive images in metastatic sites and four false-negative images in metastatic sites. Overall sensitivity for tumors in 97 individual sites was 85%, whereas specificity was 96%. Unsuspected areas of malignancy were seen in the lumbar subdural space, pleura, liver, thyroid, and lung. Besides tumor accumulations, homogeneous uptake was observed in normal liver and spleen. Radiation doses to these two organs were 2.2 and 2.9 cGy/0.5 mCi In-111, respectively. Whole body radiation dose was 0.3 cGy/0.5 mCi. The use of Indium-111-labeled vesicles permits a wide variety of human tumors in primary and metastatic sites to be imaged without toxicity and with radiation doses comparable to other radionuclide scanning techniques.

• Research Organization: Wilshire Oncology Medical Group, West Covina, CA (USA)
• OSTI ID: 6735492
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 62:5; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
CARCINOMAS
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
ESTERS
FEMALE GENITALS
GASTROINTESTINAL TRACT
GLANDS
IMMUNE SYSTEM DISEASES
INDIUM 111
INDIUM ISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINES
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LARGE INTESTINE
LIPIDS
LIVER
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
MALE GENITALS
MAMMARY GLANDS
METASTASES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PATIENTS
PHOSPHOLIPIDS
PROSTATE
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SARCOMAS
SCINTISCANNING
SENSITIVITY ANALYSIS
SKELETON
SPECIFICITY
SPINAL CORD
THYROID
UPTAKE
UTERUS