Significance of mass and number of fibers in the correlation of V79 cytoxicity with tumorigenic potential of mineral fibers

Journal Article · Mon Aug 01 04:00:00 EDT 1988 · Environ. Res.; (United States)

OSTI ID:6728218

Palekar, L D; Most, B M; Coffin, D L

The cytotoxicity of four tumorigenic minerals: erionite(w), erionite(c), UICC crocidolite, UICC chrysotile and nontumorigenic mordenite was compared in Chinese hamster lung V79 cells. The results indicate that the tumorigenic minerals were toxic by showing more than 50% toxicity for at least one dose between 10 and 100/sup +/g/ml. Mordenite was nontoxic. Higher potency of erionite, however, was not evident in this system when the dose considered was expressed in mass units. On the other hand, when the degree of cytotoxicity was considered per number of mineral fibers, it was clear that fewer erionite fibers of all three dimensions (A greater than or equal to 3; L greater than or equal to 8.0 ..mu..m, W less than or equal to 0.25 ..mu..m; and L less than or equal to 5.0 ..mu..m, W less than or equal to 0.1 ..mu..m) than those of UICC crocidolite and UICC chrysotile were needed to produce similar toxicity. This suggests that the dose in number of fibers may be a better parameter than the total mass dose as a correlate of tumorigenic potential.

• Research Organization: Northrop Services, Inc., Research Triangle Park, NC (USA)
• OSTI ID: 6728218
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 46:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASBESTOS
BODY
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
FIBERS
HAMSTERS
INORGANIC ION EXCHANGERS
ION EXCHANGE MATERIALS
LUNGS
MAMMALS
MATERIALS
MINERALS
ORGANS
PATHOGENESIS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES
ZEOLITES