Changing topographic patterns of human cerebral blood flow with age measured by xenon CT

Journal Article · Tue May 01 04:00:00 EDT 1984 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.142.5.1027· OSTI ID:6728011

Tachibana, H; Meyer, J S; Okayasu, H; Kandula, P

Changes in cerebral blood flow with age have been of long-standing interest. A study of 20 normal, healthy, right-handed volunteers 20-100 years old using a noninvasive method is reported. Local cerebral blood flow (LCBF) and partition coefficients (Llambda) were measured during inhalation of 35% stable xenon gas and serial computed tomographic (CT) scanning (CT-CBF). Relatively higher LCBF values were measured bilaterally in the cortex of occipital and frontal lobes; no significant differences were noted between left and right hemispheres. Significant age-related declines in LCBF values were observed for all cortical and subcortical gray and white matter regions of interest examined. Age-related declines were steepest in the cortex of the frontal lobes, particularly prefrontal cortex, caudate, putamen, and lentiform nuclei. Speech and visual cortical regions, functionally active throughout the normal life span, showed less age-related decline compared with all other regions, particularly prefrontal.

• Research Organization: Baylor Coll. of Medicine, Houston, TX
• OSTI ID: 6728011
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 142:5; ISSN AAJRD
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
EVEN-ODD NUCLEI
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
PHYSIOLOGY
RADIOISOTOPES
TOMOGRAPHY
XENON 133
XENON ISOTOPES