Xenon contrast CT-CBF scanning of the brain differentiates normal age-related changes from multi-infarct dementia and senile dementia of Alzheimer type

Journal Article · Sun Jul 01 00:00:00 EDT 1984 · J. Gerontol.; (United States)

DOI:https://doi.org/10.1093/geronj/39.4.415· OSTI ID:6348992

Tachibana, H; Meyer, J S; Okayasu, H; Shaw, T G; Kandula, P; Rogers, R L

Local cerebral blood flow (LCBF) and partition coefficients (L lambda) were measured during inhalation of stable xenon gas with serial CT scanning among normal volunteers (N . 15), individuals with multi-infarct dementia (MID, N . 10), and persons with senile dementia of Alzheimer type (SDAT, N . 8). Mean gray matter flow values were reduced in both MID and SDAT. Age-related declines in LCBF values in normals were marked in frontal cortex and basal ganglia. LCBF values were decreased beyond normals in frontal and temporal cortices and thalamus in MID and SDAT, in basal ganglia only in MID. Unlike SDAT and age-matched normals, L lambda values were reduced in fronto-temporal cortex and thalamus in MID. Multifocal nature of lesions in MID was apparent. Coefficients of variation for LCBFs were greater in MID compared with SDAT and/or age-matched normals.

• Research Organization: Veterans Administration Medical Center, Houston, TX
• OSTI ID: 6348992
• Journal Information: J. Gerontol.; (United States), Journal Name: J. Gerontol.; (United States) Vol. 39:4; ISSN JOGEA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
BLOOD FLOW
BODY
BRAIN
CAT SCANNING
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
INHALATION
INTAKE
ISOTOPES
MEASURING METHODS
MENTAL DISORDERS
NERVOUS SYSTEM
ORGANS
PATIENTS
TOMOGRAPHY
XENON ISOTOPES