Gluconeogenesis in the ruminant fetus: evaluation of conflicting evidence from radiotracer and other experimental techniques

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Fed. Proc.; (United States)

OSTI ID:6726746

Prior, R L

Conflicting evidence exists as to whether the gluconeogenetic process is active in the late gestation fetal lamb. In vitro evidence based on measurements of enzyme activity and substrate flux into glucose indicates that the capacity for gluconeogenesis exists in fetal liver. The in vivo conversion of (/sup 14/C)lactate and (/sup 14/C)alanine into glucose in the lamb fetus has been demonstrated. Lactate and alanine account for 49 and 2.3% of the fetal glucose pool, respectively. Although gluconeogenesis can occur in the fetal lamb, alterations in net rates of umbilical uptake of glucose or lactate, fetal blood glucose concentrations, fetal or maternal glucose replacement rates, or maternal nutrition may alter the observed rates of fetal gluconeogenesis.

• Research Organization: Meat Animal Research Center, Clay Center, NE
• OSTI ID: 6726746
• Journal Information: Fed. Proc.; (United States), Journal Name: Fed. Proc.; (United States) Vol. 41:1; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALANINES
ALDEHYDES
AMINO ACIDS
ANIMALS
BIOSYNTHESIS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
DOMESTIC ANIMALS
ENZYME ACTIVITY
FETUSES
GLUCOSE
HEXOSES
IN VIVO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTATES
MAMMALS
MONOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
RUMINANTS
SACCHARIDES
SHEEP
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES