Short-term respiratory effects of 0. 12 ppm ozone exposure in volunteers with chronic obstructive pulmonary disease

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:6723905

Linn, W S; Fischer, D A; Medway, D A; Anzar, U T; Spier, C E; Valencia, L M; Venet, T G; Hackney, J D

Twenty-five volunteers with chronic obstructive pulmonary disease of mild to moderately severe degree underwent 1-h exposures to 0.12 ppm ozone (O/sub 2/) in purified air with intermittent mild exercise. Their responses were assessed in terms of forced expiratory performance, ear oximetry, and reported symptoms. Control studied consisted of similar exposures to purified air alone. Control studies were separated from O/sub 2/ exposures by 1 month, and the order was randomized. All studies took place in a controlled-environment chamber, and were preceded by approximately 1 h of rest in a purified-air environment. No significant disturbances in forced expiratory performance or symptoms attributable to O/sub 2/ exposure were found. A slight but significant tendency to decreased arterial hemoglobin oxygen saturation (SaO/sub 2/) during exercise in O/sub 2/ was observed. The decrement in SaO/sub 2/ with O/sub 2/ relative to clean air (mean 1.3%) was near the limit of resolution of the ear oximeter test and was detected by signal averaging, thus its physiologic or clinical significance is uncertain.

• Research Organization: Environmental Health Service, Rancho Los Amigos Hospital Campus, University of Southern California School of Medicine, Downey
• OSTI ID: 6723905
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 125:6; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL EFFECTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EXERCISE
OZONE
PATIENTS
RESPIRATION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
SYMPTOMS
THERAPY