Controlled exposure of volunteers with chronic obstructive pulmonary disease to sulfur dioxide

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(85)90126-4· OSTI ID:5145313

Linn, W S; Fischer, D A; Shamoo, D A; Spier, C E; Valencia, L M; Anzar, U T; Hackney, J D

Twenty-four volunteers with chronic obstructive pulmonary disease (COPD) were exposed to sulfur dioxide (SO/sub 2/) at 0, 0.4, and 0.8 ppm in an environmental control chamber. Exposures lasted 1 hr and included two 15-min exercise periods (mean exercise ventilation rate 18 liter/min). Pulmonary mechanical function was evaluated before exposures, after initial exercise, and at the end of exposure. Blood oxygenation was measured by ear oximetry before exposure and during the second exercise period. Symptoms were recorded throughout exposure periods and for 1 week afterward. No statistically significant changes in physiology or symptoms could be attributed to SO/sub 2/ exposure. Older adults with COPD seem less reactive to a given concentration of SO/sub 2/ than heavily exercising young adult asthmatics. This may be due to lower ventilation rates (i.e., lower SO/sub 2/ dose rates) and/or to lower airway reactivity in the COPD group.

• Research Organization: Univ. of Southern California, Downey
• OSTI ID: 5145313
• Journal Information: Environ. Res.; (United States), Vol. 37:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
BIOLOGICAL FUNCTIONS
SULFUR DIOXIDE
BIOLOGICAL EFFECTS
EXERCISE
EXPERIMENTAL DATA
EXPOSURE CHAMBERS
PATIENTS
PHYSIOLOGY
RESPIRATORY SYSTEM DISEASES
SYMPTOMS
BODY
CHALCOGENIDES
DATA
DISEASES
FUNCTIONS
INFORMATION
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
SULFUR COMPOUNDS
SULFUR OXIDES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)