Sequence of bronchoalveolar lavage and histopathologic findings in rat lungs early in inhalation asbestos exposure

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709530968· OSTI ID:6723777

Smith, C M; Batcher, S; Catanzaro, A; Abraham, J L; Phalen, R

To assess the early cellular inflammatory response of the lungs, 7 rats per group were exposed nose-only to 13 mg/m/sup 3/ of chrysotile asbestos, 7 h/day for 2, 4, or 6 wk. Lung histopathology and bronchoalveolar lavage (BAL) were analyzed. In exposed animals, dose-related bronchiolitis and fibrosis were found that were not seen in control rats. In exposed rats, total BAL cells were increased six- to sevenfold over matched controls, and more cells were retrieved with longer exposure. In the BAL, counts of macrophages, lymphocytes, and polymorphonuclear cells (PMNs) were each elevated in the exposed rats. PMNs seen histologically in the BAL may be related to the time period examined. PMNs and lymphocytes observed throughout this 6-wk study support the idea that these cells may have an important role in early events of asbestos lung injury.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 6723777
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 20:1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

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ANIMAL CELLS
ANIMALS
ASBESTOS
BIOLOGICAL MATERIALS
BLOOD
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BODY
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CONNECTIVE TISSUE CELLS
FIBROSIS
HISTOLOGY
INFLAMMATION
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INTAKE
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LEUKOCYTES
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MACROPHAGES
MAMMALS
MATERIALS
ORGANS
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PHAGOCYTES
RATS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SYMPTOMS
TIME DEPENDENCE
TOXICITY
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