Implications of the quadratic cell survival curve and human skin radiation ''tolerance doses'' on fractionation and superfractionation dose selection
An analysis of early published multifraction orthovoltage human acute skin irradiation tolerance isoeffect doses is presented. It indicates that human acute skin radiation reactions may result from the repetition, with each dose fraction, of a cell survival curve of the form: S = e/sup -(..cap alpha..D + ..beta..D/sup 2/)/). The analysis also shows no need for an independent proliferation related time factor for skin, for daily treatments of six weeks or less in duration. The value obtained for the constant ..beta../..cap alpha.. for orthovoltage irradiation from these data is 2.9 x 10/sup -3/ rad/sup -1/ for the cell line determining acute skin tolerance. A radiation isoeffect relationship, based on the quadratic cell survival curve, is introduced for human skin. This relationship has some advantages over the nominal standard dose (NSD). First, its use is not restricted to tolerance level reactions. Second, a modification of the relationship, which is also introduced, may be employed in the selection of doses per treatment when irradiation dose fractions are administered at short intervals where repair of sublethal injury is incomplete.
- Research Organization:
- Cancer Control agency of British Columbia, Vancouver, Canada
- OSTI ID:
- 6722759
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:7; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL PROLIFERATION
DOSES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
ISODOSE CURVES
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RECOVERY
REPAIR
SKIN
SURVIVAL CURVES
THERAPY
VERTEBRATES
X RADIATION