Tests for the fit of the linear-quadratic model to radiation isoeffect data
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The linear-quadratic (LQ) model for cell survival is frequently extended to describe multifraction isoeffect data via the formula: In(response) = -n(..cap alpha..d + ..beta..d/sup 2/), where d is the dose per fraction and n is the number of fractions. However, estimates of the quantity ..cap alpha../..beta.. derived from such data are meaningless unless the use of the model is justified. Two methods are proposed for testing the fit of the multifraction LQ model to isoeffect data. If the use of the model cannot be rejected, each method also provides a new technique for estimating ..cap alpha../..beta... The two methods are applied to published data from spleen, kidney, and colon. In each case, consistent results are obtained from the two methods concerning the quality of the fit.
- Research Organization:
- Univ. of Texas System Cancer Center, Houston
- OSTI ID:
- 6269396
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:10; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COLONY FORMATION
CRYPT CELLS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
INTESTINES
IRRADIATION
KIDNEYS
LARGE INTESTINE
MATHEMATICAL MODELS
ORGANS
RADIATION EFFECTS
SOMATIC CELLS
SPLEEN
SPLEEN COLONY FORMATION
SURVIVAL CURVES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COLONY FORMATION
CRYPT CELLS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
INTESTINES
IRRADIATION
KIDNEYS
LARGE INTESTINE
MATHEMATICAL MODELS
ORGANS
RADIATION EFFECTS
SOMATIC CELLS
SPLEEN
SPLEEN COLONY FORMATION
SURVIVAL CURVES