Immunological recovery in 48 patients following syngeneic marrow transplantation for hematological malignancy. [/sup 60/Co]

Journal Article · Mon Feb 01 04:00:00 EST 1982 · Transplantation; (United States)

OSTI ID:6722658

Whiterspoon, R P ^[1]; Kopecky, K; Storb, R F

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1. Fred Hutchinson Cancer Research Center, Seattle, WA

Immunological function of 48 syngeneic transplant patients prepared with 120 mg of cyclophosphamide per kg and 9.2 to 12.0 Gy (920 to 1000 rad) total body irradiation was compared with that of 153 allogeneic recipients. Lymphocyte counts and T cell numbers in syngeneic recipients were low during the first post-transplant month but higher than those of allogeneic recipients. Serum immunoglobulin levels in syngeneic recipients were normal by completion of the first post-transplantation month and were higher than allogeneic recipients at that time. Total hemolytic complement (CH/sub 50/) and third (C3) and fourth (C4) components were normal throughout the post-transplantation course in both groups of patients. Antibody production to primary injection of bacteriophage THETAX174 (Phage) was low in both syngeneic and allogeneic recipients during the first post-transplantation month and rose gradually thereafter. Some syngeneic recipients failed to produce normal amounts of IgG in their secondary response to phage. Antibody production after primary and secondary injection of keyhole limpet hemocyanin or pneumococcal polysaccharide was lower than normal early after grafting and rose later, comparable to that seen in allogeneic recipients. We conclude that immunological recovery in syngeneic recipients is very similar to recovery in allogeneic recipients except in the first month postgrafting where twins are slightly better than allogeneic recipients for lymphocyte and immunoglobulin levels. Other mechanisms than those listed here must play an important role in protecting the syngeneic marrow graft recipient from opportunistic infection. (JMT)

• OSTI ID: 6722658
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 33:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANIMAL TISSUES
ANTIBODY FORMATION
BACTERIOPHAGES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
EXTERNAL IRRADIATION
GAMMA RADIATION
GLOBULINS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IMMUNOGLOBULINS
IMMUNOSUPPRESSION
IMMUNOSUPPRESSIVE DRUGS
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASITES
PATIENTS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
SOMATIC CELLS
THERAPY
TISSUES
TRANSPLANTS
VIRUSES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES