Effect of dihydroxyanthraquinone (NSC 279836) and thoracic irradiation on long-term survival of rats

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · Cancer Res.; (United States)

OSTI ID:6721266

Kimler, B F; Henderson, S D; Mansfield, C M; Svoboda, D J; Cheng, C C

Dihydroxyanthraquinone (DHAQ; NSC 279836) is a recently synthesized compound that is structurally similar to Adriamycin and produces greater antitumor effects in murine model systems. Researchers compared DHAQ to Adriamycin in rats, with and without irradiation of the chest at various intervals after drug treatment. A single injection of Adriamycin (1 mg/kg i.p.) had little effect on animal survival, even if combined with radiation (12 Gy 25 MV X-rays), greater than 90% being alive at 1 year. A single injection of DHAQ (3 mg/kg i.p.) was equally uneffective up to 200 days after treatment (survival, greater than 90%). However, between 200 and 370 days after treatment, all animals died, producing a median survival time of 280 days. Further, when DHAQ was combined with radiation, there was an increase in animal deaths between Days 300 and 200. For animals irradiated on Days 0, 43, and 93 after DHAQ treatment, only 50, 75, and 80%, respectively, survived to Day 200. All animals that survived past Day 200 subsequently died by 1 year, displaying the same kinetics of lethality as those animals that had received DHAQ only. A repeat experiment using DHAQ at 1 mg/kg produced similar results. Based on these findings, researchers conclude that DHAQ produces a long-term (greater than 200 days) toxicity in rats that is not detectable by short-duration toxicity screening. In addition, radiation enhances short-term (less than 200 days) lethality, with the degree of enhancement decreasing as the interval between drug and radiation is increased.

• Research Organization: Departments of Radiation Therapy and Pathology, University of Kansas Medical Center, Kansas City
• OSTI ID: 6721266
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 42:7; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560152 -- Radiation Effects on Animals-- Animals
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTHRAQUINONES
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CHEST
COMPARATIVE EVALUATIONS
DOSES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGY
QUINONES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SURVIVAL CURVES
TOXICITY
VERTEBRATES
X RADIATION