Alterations within the rat thyroid gland during vitamin A deficiency
Thyroid glands from female rats kept vitamin A deficient for one, two, and three months were examined by electron microscopy. After one month on the diet, no consistent alterations were noted. After two months, the colloid in some follicles displayed a peripheral zone of decreased density. In addition, ultimobranchial follicles within the gland had become keratinized. After two to three months on the diet, cells were seen entering the colloid. Many of these cells were identified as follicular cells. Quantitative and autoradiographic studies indicated that thyroids of vitamin A deficient rats took up less radioiodide than thyroids of control rats. It's possible that the presence of follicular cells in the colloid reflects an accelerated turnover of these cells and could indicate an early pathological sign.
- Research Organization:
- Univ. of Maryland, Baltimore
- OSTI ID:
- 6719638
- Journal Information:
- Am. J. Anat.; (United States), Vol. 156:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IODINE ISOTOPES
UPTAKE
NUTRITIONAL DEFICIENCY
PATHOGENESIS
THYROID
ULTRASTRUCTURAL CHANGES
VITAMIN A
ACID PHOSPHATASE
AUTORADIOGRAPHY
ELECTRON MICROSCOPY
NEOPLASMS
RATS
ANIMALS
BODY
DISEASES
ENDOCRINE GLANDS
ENZYMES
ESTERASES
GLANDS
HYDROLASES
ISOTOPES
MAMMALS
MICROSCOPY
MORPHOLOGICAL CHANGES
ORGANS
PHOSPHATASES
RODENTS
VERTEBRATES
VITAMINS
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)