The Effect of Vitamins B$sub 1$ and B$sub 12$ and Benzedrine and Phenobarbital on the Thyroid Function Studied with Radioactive Iodine (I$sup 131$); L'ACTION DES VITAMINES B$sub 1$ ET B$sub 12$ AINSI QUE DE LA BENZEDRINE ET DU PHENOBARBITAL SUR LA FONCTION THYROIDIENNE ETUDIEE A L'AIDE DE L'IODE RADIOACTIF (I$sup 131$)

Technical Report · Sat Oct 31 04:00:00 EST 1959

OSTI ID:4270055

Lupulescou, A; Negoescou, I; Pop, Al; Cocou, Fl

The effects of vitamins B/sub 1/ and B/sub 12/ and benzedrine and perimental gioters, obtained by an iodine-deficient diet in rats for 9 to 10 months, were studied. Five days before sacrificing the animals, the uptake of radioiodine was determined by administering to each 4 mu c of I/sup 131/ intraperitoneally. The determinations were made with a Geiger counter 4, 24, 48, 72, and 100 hours after the injection. After sacrifice, the thyroid, hypophysis, and suprarenals were removed. The uptake of I/sup 131/ the basal metabolism, the weight of the animals and of the thyroid gland, and the histologic structure were determined. The results showed that vitamin B/sub 1/ decreased the iodine uptake, and vitamin B/sub 12/, benzedrine, and phenobartial increased it. In the rats with a iodine-deficent diet, creased the iodine uptake. Vitamin B/sub 12/ and benzedrine increased the basal d thyroid he histologic results are discused. (J.S.R.)

• Research Organization: Inst. d'Endocrinologie, Bucharest
• NSA Number: NSA-13-006335
• OSTI ID: 4270055
• Report Number(s): A/CONF.15/P/2512
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
AGE
AMINES
BARBITURIC ACID
BENZEDRINE
BIOLOGY AND MEDICINE
DIET
DISEASES
DRUGS
GEIGER-MUELLER COUNTERS
GLANDS
GOITER
HYPERTHYROIDISM
IODINE
IODINE 131
METABOLISM
PHENOBARBITAL
PITUITARY GLAND
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RATS
THYROID
TISSUES
TOXICITY
TRACER TECHNIQUES
VITAMIN B-1
VITAMIN B-12
VITAMINS
WEIGHT