Chemical, biomedical and ecological studies of SRC-I materials from the Fort Lewis Pilot Plant: a status report

Technical Report · Thu Jan 01 04:00:00 EST 1981

DOI:https://doi.org/10.2172/6719546· OSTI ID:6719546

Mahlum, D D ^[1]

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1. ed.

This document discusses studies performed with solvent refined coal (SRC) materials obtained from the Fort Lewis Pilot Plant during operation in the SRC-I mode. The development of analytical methodology is presented as well as results obtained from the application of these methods to light oil (LO), wash solvent (WS) and process solvent (PS). Results of cellular and animal studies with LO, WS and PS are included, along with a description of methods for the generation and characterization of LO and PS aerosols, and for exposing rats, mice and guinea pigs to these aerosols. The effects of SRC-I product on seed germination and plant growth which have also been studied are discussed. The SRC-I product, feed coal and the mineral residue have been analyzed for organic and inorganic constituents. The higher-boiling-point material, PS, exhibited significant mutagenic activity in the Ames assay; LO and WS were inactive. Process solvent also caused transformation of cultured Syrian hamster embryo cells. Additional chemical fractionation studies suggest that primary aromatic amines are major determinants of the observed mutagenic activity. Skin-painting studies with SRC-II naphtha, heavy distillate, shale oil and petroleum crude indicate a good correlation between the results of the cellular assays and skin carcinogenesis in mice. Wash solvent was more toxic after oral administration to rats than was light oil or process solvent. The effects of LO, WS and PS on development were studied after administration to pregnant rats. The tissue distribution of a number of components of PS was studied after oral administration of PS to rats. The effect of SRC-I product on the germination and growth of barley was investigated by mixing or layering the product with soil and placing the mixture in a field lysimeter.

• Research Organization: Battelle Columbus Labs., OH (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6719546
• Report Number(s): PNL-3474
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
010600 -- Coal
Lignite
& Peat-- Properties & Composition
010900 -- Coal
Lignite
& Peat-- Environmental Aspects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
560303 -- Chemicals Metabolism & Toxicology-- Plants-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ANALYSIS
AMINES
ANIMALS
AROMATICS
BACTERIA
BARLEY
BARYON REACTIONS
BIOASSAY
BIOLOGICAL EFFECTS
BODY
CELL CULTURES
CEREALS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
COAL LIQUIDS
DISPERSIONS
DISTRIBUTION
FLUIDS
FUELS
GAS CHROMATOGRAPHY
GERMINATION
GRAMINEAE
GRASS
GROWTH
GUINEA PIGS
HADRON REACTIONS
HAMSTERS
LIQUID COLUMN CHROMATOGRAPHY
LIQUIDS
MAMMALS
MASS SPECTROSCOPY
MICE
MICROORGANISMS
MIXTURES
MUTAGENS
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANIC COMPOUNDS
ORGANS
PLANT GROWTH
PLANTS
PRENATAL EXPOSURE
PROCESS SOLUTIONS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SEPARATION PROCESSES
SKIN
SOLUTIONS
SOLVENT-REFINED COAL
SOLVENTS
SPECTROSCOPY
SRC PROCESS
SRC PROCESS ACTIVATION ANALYSIS
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES