Carcinogenicity of deuterium-labeled N-nitroso-N-methylcyclohexylamine in rats
Journal Article
·
· JNCI, J. Natl. Cancer Inst.; (United States)
OSTI ID:6719356
F344 rats were treated with both unlabeled N-nitroso-N-methylcyclohexylamine (NMC) and deuterium-labeled NMC (NMC-d3) in the methyl group. Both compounds were administered in the drinking water at concentrations of 50 and 12.5 mg/liter. The NMC-d3 was not less carcinogenic than the unlabeled NMC, which suggested that oxidation of the methyl group is not a rate-limiting step in the induction of esophageal tumors.
- Research Organization:
- NCI Frederick Cancer Research Center, MD
- OSTI ID:
- 6719356
- Journal Information:
- JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 64:6; ISSN JJIND
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DEUTERIUM COMPOUNDS
DIGESTIVE SYSTEM
DISEASES
ESOPHAGUS
HYDROGEN COMPOUNDS
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RADIONUCLIDE KINETICS
RATS
RODENTS
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DEUTERIUM COMPOUNDS
DIGESTIVE SYSTEM
DISEASES
ESOPHAGUS
HYDROGEN COMPOUNDS
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RADIONUCLIDE KINETICS
RATS
RODENTS
VERTEBRATES