Carcinogenesis in Syrian hamsters by N-nitroso-2,6-dimethylmorpholine, its cis and trans isomers, and the effect of deuterium labeling

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/2.8.731· OSTI ID:5477229

Rao, M S; Scarpelli, D G; Lijinsky, W

Groups of 20 Syrian male golden hamsters were treated by gavage with solutions of the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine in olive oil. Two doses of each isomer were given for the same time and the ratios of the concentrations corresponded with the ratio in the normally prepared mixture, 2 parts cis to 1 part trans. The cis isomer was more potent in inducing tumors of the liver and pancreas than the trans isomer. The effect of replacement of hydrogen with deuterium at the positions alpha and beta to the nitroso function on carcinogenic potency was examined by administering by gavage the respective isotopically labeled compounds to groups of 20 male hamsters. Each labeled sample constituted a mixture of cis and trans isomers in the ratio of approximately 2 to 1, and the dose was identical with that of the unlabeled sample of the nitrosamine. The beta deuterium labeled compound was less carcinogenic and the alpha deuterium labeled compound was more carcinogenic than the unlabeled material. There was not significant difference between the isomers in activation to a bacterial mutagen by pancreas microsomes or in binding to DNA of the pancreas.

• Research Organization: Department of Pathology and the Cancer Center, Northwestern University Medical School, Chicago, IL
• OSTI ID: 5477229
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 2:8; ISSN CRNGD
• Country of Publication: United States
• Language: English

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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BACTERIA
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CELL CONSTITUENTS
DEUTERIUM COMPOUNDS
DIGESTIVE SYSTEM
DISEASES
DNA
ENDOCRINE GLANDS
ETHERS
GLANDS
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
ISOMERS
LIVER
MAMMALS
METABOLIC ACTIVATION
MICROORGANISMS
MICROSOMES
MORPHOLINES
NEOPLASMS
NITROSO COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PANCREAS
PATHOGENESIS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
VERTEBRATES