Restricted nucleocytoplasmic relationship in activation of T and B lymphocytes
Journal Article
·
· J. Exp. Med.; (United States)
Nuclei of murine T lymphocytes or B lymphocytes were purified and transferred into lethally irradiated whole spleen cells or B or T lymphocytes by means of polyethyleneglycol-mediated cell fusion. Transfer of lymphocyte nuclei could save the irradiated cells from cell death, and such reconstituted cells could respond to mitogens. The present study showed that nuclei of T cells could be activated in the concanavalin A-stimulated T cell cytoplasms but not in the lipopolysaccharide-stimulated B cell cytoplasms. On the other hand, nuclei of B cells were activated in the lipopolysaccharide-stimulated B cells but not in the concanavalin A-stimulated T cell cytoplasms. These data suggested that a specific interaction between cytoplasm and nucleus might exist in the activation of nuclei of each lymphocyte subset.
- Research Organization:
- Department of Immunology, Saga Medical School, Japan
- OSTI ID:
- 6718943
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 156:1; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550300* -- Cytology
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMAL CELLS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CELL NUCLEI
CHEMICAL ACTIVATION
COMPARATIVE EVALUATIONS
CONCANAVALIN
CONNECTIVE TISSUE CELLS
CYTOPLASM
EXTERNAL IRRADIATION
HEMAGGLUTININS
IMMUNOLOGY
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
RADIATION EFFECTS
SOMATIC CELLS
SPLEEN CELLS
550300* -- Cytology
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMAL CELLS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CELL NUCLEI
CHEMICAL ACTIVATION
COMPARATIVE EVALUATIONS
CONCANAVALIN
CONNECTIVE TISSUE CELLS
CYTOPLASM
EXTERNAL IRRADIATION
HEMAGGLUTININS
IMMUNOLOGY
IRRADIATION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
RADIATION EFFECTS
SOMATIC CELLS
SPLEEN CELLS