The multichain interleukin 2 receptor: A target for immunotherapy in lymphoma, autoimmune disorders, and organ allografts

Journal Article · Fri Jan 12 04:00:00 EST 1990 · JAMA, Journal of the American Medical Association; (USA)

DOI:https://doi.org/10.1001/jama.263.2.272· OSTI ID:6718456

Waldmann, T A ^[1]

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1. National Institutes of Health, Bethesda, MD (USA)

The use of chemotherapeutic agents has cured some types of human cancer. However, many types of cancer either are initially unresponsive or subsequently acquire resistance to chemotherapy. Many in vitro studies have shown selective high-affinity binding of monoclonal antibodies to tumor cells. However, such monoclonal antibodies have to data been relatively ineffective. In the case selected for presentation, the authors used the anti-Tac monoclonal antibody. This antibody is directed against the receptor for IL-2, a receptor expressed on ATL cells but not resting cells. The authors developed alternative cytotoxic agents that could be conjugated to anti-Tac and are effective when bound to the surface of Tac-expressing cells. In one case, they showed that {sup 212}Bi, an {alpha}-emitting radionuclide, conjugated to anti-Tac was well suited for this role. In parallel studies, they bound the {beta}-emitting {sup 90}Y to anti-Tac using chelates that did not permit elution of radiolabeled yttrium from the monoclonal antibody. Rhesus monkeys that received xenografts of cynomolgus hearts showed a marked prolongation of xenograft survival following administration of {sup 90}Y-labeled anti-Tac. Thus, {sup 212}Bi-labeled anti-Tac and {sup 90}Y-labeled anti-Tac are potentially effective and specific immunocytotoxic agents for the elimination of Tac-expressing cells.

• OSTI ID: 6718456
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Journal Name: JAMA, Journal of the American Medical Association; (USA) Vol. 263:2; ISSN 0098-7484; ISSN JAMAA
• Country of Publication: United States
• Language: English

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550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMAL CELLS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH 212
BISMUTH ISOTOPES
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DISEASES
GRAFTS
GROWTH FACTORS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNE SYSTEM DISEASES
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPHOKINES
LYMPHOMAS
MAMMALS
MEDICINE
MEMBRANE PROTEINS
MITOGENS
MONKEYS
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PRIMATES
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECEPTORS
THERAPY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
YTTRIUM 90
YTTRIUM ISOTOPES