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Mucociliary clearance and particle retention in the maxillary and ethmoid turbinate regions of beagle dogs

Journal Article · · J. Toxicol. Environ. Health; (United States)
; ; ;

In this study, the retention and clearance of particles instilled onto the epithelium at two sites in the nasal cavity were examined. Polystyrene microspheres (3 ..mu..m geometric diameter) were labeled with /sup 141/Ce or /sup 85/Sr and instilled simultaneously on the maxillary and ethmoid turbinates of beagle dogs. The retention and clearance patterns of the microspheres were followed for 30 d after instillation. Tissue samples, excreta content, and autoradiography of the radiolabels provided the basis for defining the fate of the microspheres or the radiolabels dissolved from the microspheres. Early nasal mucus velocity was significantly faster from the maxillary turbinate region than from the ethmoid turbinate region. Retention at both instillation sites at 30 d after instillation was approximately 0.1% of the amount initially instilled. Radioactivity was excreted primarily via the feces during the first few days. Radiolabel measured in urine and tissues other than turbines was small, indicating minimal dissolution of the radiolabel from the particles. Autoradiographs of turbinate tissue revealed particles sporadically located in the epithelial submucosa. From these data, it was concluded that a significant difference in early clearance for particles exists between the ethmoid and maxillary turbinates, but there was no difference in the fraction of particles retained in these two areas for long periods of time.

Research Organization:
Inhalation Toxicology Research Institute, Albuquerque, NM
DOE Contract Number:
AC04-76EV01013
OSTI ID:
6715559
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 19:4; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CERIUM 141
CERIUM ISOTOPES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EPITHELIUM
EVEN-ODD NUCLEI
EXCRETION
FECES
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEMBRANES
MICROSPHERES
MUCOUS MEMBRANES
NUCLEI
ORGANS
PARTICLES
PARTICULATES
PHARYNX
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RESPIRATORY SYSTEM
RETENTION
STRONTIUM 85
STRONTIUM ISOTOPES
TISSUES
URINE
VERTEBRATES
WASTES