Reduction of nitroimidazoles in model chemical and biological systems
Some chemical and biological properties of intermediates obtained during reduction of nitroimidazoles are discussed. These include: rate data for the decay of the nitro radical-anion, stoichiometry and absorption spectra for reduction via the radical-anion or using dithionite, stoichiometry with other reducing agents, and rate of reduction by xanthine/xanthine oxidase. Increased radiosensitization by misonidazole is seen upon prolonged pre-irradiation incubation using E. coli, enabling demonstration that a freely-diffusable metabolite is responsible for this effect. Preliminary experiments designed to extend studies of the radiobiological properties of extracellularly-added metabolites to mammalian cells and the use of liver perfusion to generate metabolites are described.
- Research Organization:
- Mount Vernon Hospital, Northwood, England
- OSTI ID:
- 6714821
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560302 -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTRA
AMINES
AZOLES
BACTERIA
CHEMICAL REACTIONS
ENZYMES
ESCHERICHIA COLI
HETEROCYCLIC COMPOUNDS
HYDROXYLAMINE
IMIDAZOLES
METABOLITES
MICROORGANISMS
NITRO COMPOUNDS
NITRO-GROUP DEHYDROGENASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
OXYGENASES
RADIOSENSITIVITY EFFECTS
REDUCTION
SPECTRA
STOICHIOMETRY