Oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system
Radiation chemical reductions using e/sub aq//sup -/ and CO/sub 2//sup -/ have been carried out in the presence of oxygen with metronidazole, p-nitroacetophenone, misonidazole and three other 2-nitroimidazoles. Low concentrations of oxygen were found to effectively inhibit the reduction of the first two compounds while much higher concentrations of oxygen were required for all of the 2-nitroimidazoles. Kinetic modelling of the radiochemical system suggests that the explanation for the differences lies in different reactions of the nitro radical anions; it appears that the anion derived from metronidazole undergoes disproportionation while that derived from misonidazole undergoes a unimolecular decay.
- Research Organization:
- Ontario Cancer Inst., Toronto
- OSTI ID:
- 6363232
- Report Number(s):
- CONF-8311204-
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:8; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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400600* -- Radiation Chemistry
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59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL DOSEMETERS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
COBALT 60
COBALT ISOTOPES
DECOMPOSITION
DOSEMETERS
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
INHIBITION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEPTONS
MEASURING INSTRUMENTS
METRONIDAZOLE
MINUTES LIVING RADIOISOTOPES
MISONIDAZOLE
NITRO COMPOUNDS
NONMETALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
PHARMACOLOGY
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLYSIS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
REDUCTION
SOLVATED ELECTRONS
YEARS LIVING RADIOISOTOPES