Pathophysiology of coal pneumoconiosis in Equidae. Final report No. 2, 1 June 1971-31 December 1973

Technical Report · Sat Jun 01 04:00:00 EDT 1974

OSTI ID:6714173

Davis, G W; Farrell, R L; Hamlin, R L; Smith, C R; Ghosh, S

A group of 12 coal-mine ponies was studied to characterize the physiological parameters and pathological changes in spontaneous pneumoconiosis in Equidae. The six coal mines where the ponies worked were located in eastern West Virginia and western Pennsylvania. Gross lesions were seen at necropsy, similar to mild simple coal workers pneumoconiosis. None of the animals demonstrated disease comparable with the more-complicated human disease. Numerous punctate 1 millimeter to 1 centimeter coal macules were found in the lungs. The macules occurred primarily in subpleural and dependent portions of the lung, microscopically consisting of peribronchiolar aggregates of dust-laden pulmonary macrophages. Bronchiolar mucosal hyperplasia and peribronchiolar and perivascular fibrosis were also noted along with secondary emphysema and muscular hypertrophy. Ultrastructurally retained dust particles characterized the pulmonary lesions. A proliferation of alveolar type-II cells was noted. Those ponies with longer exposure periods demonstrated more severe pulmonary lesions.

• Research Organization: Ohio State Univ. Research Foundation, Columbus (USA)
• OSTI ID: 6714173
• Report Number(s): PB-88-237649/XAB
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
010900* -- Coal
Lignite
& Peat-- Environmental Aspects
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
COAL MINES
DISEASES
DOCUMENT TYPES
FEDERAL REGION III
HAZARDOUS MATERIALS
HORSES
INDUSTRIAL MEDICINE
INSPECTION
MAMMALS
MATERIALS
MEDICINE
MINES
NORTH AMERICA
OCCUPATIONAL EXPOSURE
PATHOLOGY
PENNSYLVANIA
PNEUMOCONIOSES
PROGRESS REPORT
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
TOXICITY
UNDERGROUND FACILITIES
USA
VERTEBRATES
WEST VIRGINIA