Scanning electron microscopy of lung following alpha irradiation
- Pacific Northwest Laboratory, Richland, WA (USA)
Pulmonary aggregation of inhaled {sup 239}PuO{sub 2} particles leads to a cellular evolution of focal inflammation, fibrosis, epithelial dysplasia and lung tumor formation. Female Wistar rats were exposed to an aerosol of high-fired {sup 239}PuO{sub 2} (initial lung burden, 3.9 kBq) and the lungs examined at intervals from 1 day to 700 days after exposure by light and scanning electron microscopy and autoradiography. Peribronchiolar Pu particle aggregation increased with time, resulting in well-defined focal inflammatory lesions after 120 days and fibrotic lesions after 180 days. A generalized hypertrophy and hyperplasia of nonciliated bronchiolar cells was seen at 15 days and type II cell hyperplasia by 30 days after exposure. Focal dysplastic changes in type II alveolar epithelium and terminal nonciliated bronchiolar epithelium preceded carcinoma formation. Alveolar bronchiolarization was first noted at 120 days, squamous metaplasia at 210 days, squamous carcinoma at 270 days and adenocarcinoma at 600 days after exposure.
- OSTI ID:
- 6992099
- Journal Information:
- Scanning Microscopy; (USA), Journal Name: Scanning Microscopy; (USA) Vol. 3:3; ISSN 0891-7035; ISSN SCMIE
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMALS
AUTORADIOGRAPHY
BODY
CARCINOMAS
CHARGED PARTICLES
DISEASES
ELECTRON MICROSCOPY
EVEN-ODD NUCLEI
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNGS
MAMMALS
MICROSCOPY
NEOPLASMS
NUCLEI
ORGANS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPIRATORY SYSTEM
RODENTS
SCANNING ELECTRON MICROSCOPY
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES