Scanning electron microscopy of lung following alpha irradiation
- Pacific Northwest Laboratory, Richland, WA (USA)
Pulmonary aggregation of inhaled {sup 239}PuO{sub 2} particles leads to a cellular evolution of focal inflammation, fibrosis, epithelial dysplasia and lung tumor formation. Female Wistar rats were exposed to an aerosol of high-fired {sup 239}PuO{sub 2} (initial lung burden, 3.9 kBq) and the lungs examined at intervals from 1 day to 700 days after exposure by light and scanning electron microscopy and autoradiography. Peribronchiolar Pu particle aggregation increased with time, resulting in well-defined focal inflammatory lesions after 120 days and fibrotic lesions after 180 days. A generalized hypertrophy and hyperplasia of nonciliated bronchiolar cells was seen at 15 days and type II cell hyperplasia by 30 days after exposure. Focal dysplastic changes in type II alveolar epithelium and terminal nonciliated bronchiolar epithelium preceded carcinoma formation. Alveolar bronchiolarization was first noted at 120 days, squamous metaplasia at 210 days, squamous carcinoma at 270 days and adenocarcinoma at 600 days after exposure.
- OSTI ID:
- 6992099
- Journal Information:
- Scanning Microscopy; (USA), Vol. 3:3; ISSN 0891-7035
- Country of Publication:
- United States
- Language:
- English
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CARCINOMAS
RADIOINDUCTION
LUNGS
PLUTONIUM 239
TOXICITY
ALPHA PARTICLES
AUTORADIOGRAPHY
INHALATION
RADIONUCLIDE KINETICS
RATS
SCANNING ELECTRON MICROSCOPY
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BODY
CHARGED PARTICLES
DISEASES
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HEAVY NUCLEI
INTAKE
ISOTOPES
MAMMALS
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RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
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560162* - Radionuclide Effects
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& Toxicology- Animals
Plants
Microorganisms
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