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Effect of a base-catalyzed dechlorination process on the genotoxicity of PCB-contaminated soil

Technical Report ·
OSTI ID:6713446
; ; ;
We evaluated the genotoxicity of dichloromethane (DCM) extracts of PCB-contaminated soil before and after the soil had been treated by a base-catalyzed dechlorination process, which involved heating a mixture of the soil, polyethylene glycol, and sodium hydroxide to 250-350 C. This dechlorination process reduced by over 99% the PCB concentration in the soil, which was initially 2,200 ppm. The DCM extracts of both control and treated soils were not mutagenic in strain TA100 of Salmonella, but they were mutagenic in strain TA98. The base-catalyzed dechlorination process reduced the mutagenic potency of the soil by approximately one-half. The DCM extracts of the soils before and after treatment were equally genotoxic in a prophage-induction assay in E. coli, which detects some chlorinated organic carcinogens that were not detected by the Salmonella mutagenicity assay. These results show that treatment of PCB-contaminated soil by this base-catalyzed dechlorination process did not increase the genotoxicity of the soil.
Research Organization:
Environmental Protection Agency, Research Triangle Park, NC (United States). Office of Research and Development
OSTI ID:
6713446
Report Number(s):
PB-93-141323/XAB; EPA--600/J-92/433
Country of Publication:
United States
Language:
English

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Related Subjects

54 ENVIRONMENTAL SCIENCES
540220 -- Environment
Terrestrial-- Chemicals Monitoring & Transport-- (1990-)
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METALS
AROMATICS
BACTERIA
BACTERIOPHAGES
CARCINOGENS
CATALYSIS
CHEMICAL REACTIONS
CHLORINATED AROMATIC HYDROCARBONS
CONTAMINATION
CONTROL
DATA
DECHLORINATION
DEHALOGENATION
DETECTION
ELEMENTS
ESCHERICHIA COLI
HALOGENATED AROMATIC HYDROCARBONS
HEATING
HYDROGEN COMPOUNDS
INFORMATION
METALS
MICROORGANISMS
MUTAGENS
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
OXYGEN COMPOUNDS
PARASITES
POLYCHLORINATED BIPHENYLS
POLYETHYLENES
POLYMERS
POLYOLEFINS
RAIN WATER
SALMONELLA
SODIUM
SOILS
STATISTICAL DATA
TOXICITY
VIRUSES
WATER