Distribution and metabolism of cis- and trans-resmethrin (5-benzyl-3-furyl-methyl-2,2-dimethyl 3-(2-methyl-propenyl)cyclopropanecarboxylate in laying hens

Thesis/Dissertation · Wed Jan 01 04:00:00 EST 1986

OSTI ID:6713068

Christopher, R J

The cis and trans isomers of the synthetic pyrethroid, resmethrin (5-benzyl-3-furylmethyl-(IRS)-chrysanthemate), labeled with radiocarbon in either the alcohol or acid moiety, were individually administered orally to White Leghorn laying hens at a dosage of 10 mg/kg. With each isomer and label position, greater than 90% of the radiocarbon was eliminated in the excreta within 24 hours posttreatment. Radiocarbon residues in the egg white and yolk fractions were low, with peak levels observed at 1-2 and 4-5 days post-treatment in white and yolk, respectively. Residues were considerably lower in egg whites than in yolks. In birds killed 12 hours post-treatment, radiocarbon residues in tissues were low with peak levels in liver and kidney. Unmetabolized cis- or trans-resmethrin was detected in all tissues analyzed from birds killed at 12 hours post-treatment and represented the major metabolite in fat. The majority of the tissues from hens 14 days post-treatment contained no detectable levels of radiocarbon and would appear not to be indicative of appreciable residue retention. Numerous metabolites were isolated and were present in both the free and conjugated form. The metabolic routes for both resmethrin isomers arise from ester hydrolysis and oxidation of the hydrolytic products. Certain of these metabolites are further conjugated with glucuronic acid, sulfate or other unidentified compounds before excretion.

• Research Organization: Texas A and M Univ., College Station (USA)
• OSTI ID: 6713068
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
BIRDS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CHEMICAL REACTIONS
CHICKENS
CLEARANCE
CONNECTIVE TISSUE
DISTRIBUTION
EGGS
EXCRETION
FOWL
ISOMERIZATION
LABELLED COMPOUNDS
METABOLISM
METABOLITES
ORAL ADMINISTRATION
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES