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Biliary and urinary excretion of metals in humans

Journal Article · · Arch. Environ. Health; (United States)
;
Fifteen metals (lead, cadmium, arsenic, inorganic mercury, organic mercury, iron, manganese, magnesium, chromium, zinc, copper, nickel, cobalt, tin, and aluminum) were determined in the hepatic bile and urine collected simultaneously from three Japanese individuals (2 males, 1 female). The presence of these metals was classified as follows: (1) hepatic biliary concentrations were higher than urinary concentrations (lead, arsenic, and iron); (2) urinary concentrations were higher than hepatic biliary concentrations (cadmium, inorganic mercury, tin, cobalt, magnesium, chromium, copper, zinc, and nickel); (3) hepatic biliary concentrations were almost equal to urinary concentrations (manganese and organic mercury); and (4) relationship between hepatic biliary and urinary concentrations changed occasionally (aluminium). Eight essential metals (iron, manganese, magnesium, zinc, chromium, copper, nickel, and cobalt) were detected at considerable concentrations in hepatic bile. Accounting for the daily flow volume of hepatic bile and the reabsorption of these metals, the supplementation of these metals should occur during treatment of diseases accompanied by loss of hepatic bile. 54 references.
Research Organization:
Tohoku Rasai Hospital, Sendai, Japan
OSTI ID:
6712701
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 41:5; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
ALUMINIUM
ANIMALS
ARSENIC
BILE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CADMIUM
CHEMICAL ANALYSIS
CHROMIUM
CLEARANCE
COBALT
COPPER
ELEMENTS
EXCRETION
IRON
LEAD
MAGNESIUM
MAMMALS
MAN
MANGANESE
MATERIALS
MERCURY
MERCURY COMPOUNDS
METABOLISM
METALS
NICKEL
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PRIMATES
RETENTION
SEMIMETALS
THERAPY
TIN
TRANSITION ELEMENTS
URINE
VERTEBRATES
WASTES
ZINC