Sister chromatid exchange induction in two cell lines
Journal Article
·
· Environ. Mutagen.; (United States)
Sister chromatid exchange (SCE) induction by the procarcinogen benzo(a)pyrene (BP) was studied using two established cell lines. Chinese hamster ovary (CHO) and Chinese hamster lung (Don) cells were exposed to varying concentrations of BP in the presence and absence of a rat liver metabolizing system. Results showed a significant difference in the abilities of the two cell lines to induce SCE in the absence of liver homogenate. These experiments demonstrate that Don cells are capable of generating active metabolites from biologically inactive procarinogens presumably due to an inherent metabolizing system which is deficient or absent in CHO cells.
- Research Organization:
- Univ. of Sydney, Australia
- OSTI ID:
- 6712572
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 4:3; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Sat Dec 31 23:00:00 EST 1983
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OSTI ID:6220469
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Thu Dec 31 23:00:00 EST 1981
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Sat Dec 31 23:00:00 EST 1983
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OSTI ID:5651473
Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOASSAY
BIOLOGICAL INDICATORS
BODY
CARCINOGEN SCREENING
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
FEMALE GENITALS
GONADS
HAMSTERS
HYDROCARBONS
LUNGS
MAMMALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
MUTATIONS
ORGANIC COMPOUNDS
ORGANS
OVARIES
RESPIRATORY SYSTEM
RODENTS
SCREENING
SISTER CHROMATID EXCHANGES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOASSAY
BIOLOGICAL INDICATORS
BODY
CARCINOGEN SCREENING
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
FEMALE GENITALS
GONADS
HAMSTERS
HYDROCARBONS
LUNGS
MAMMALS
METABOLIC ACTIVATION
MUTAGEN SCREENING
MUTATIONS
ORGANIC COMPOUNDS
ORGANS
OVARIES
RESPIRATORY SYSTEM
RODENTS
SCREENING
SISTER CHROMATID EXCHANGES
VERTEBRATES