Microtus oeconomus (Rodentia), a useful mammal for studying the induction of sex-chromosome nondisjunction and diploid gametes in male germ cells

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.7931151· OSTI ID:6710381

Tates, A D

A method is described for the detection of sex-chromosome nondisjunction and diploid spermatids in male germ cells of the field vole Microtus oeconomus. The method is based on the unique distribution pattern of heterochromatin in Microtus cells, which makes it possible to identify X and Y chromosomes in early spermatids with a simple C-banding procedure. With the Microtus system it has now been demonstrated that radiation of spermatocyte stages with doses of 50, 100 and 200 R results in a higher frequency of sex chromosome nondisjunction and of diploid gametes. Both types of aberrant gametes can be produced during the first and second meiotic division.

• Research Organization: State Univ. of Leiden, Netherlands
• OSTI ID: 6710381
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 31; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560153* -- Radiation Effects on Animals-- Invertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOXYLIC ACIDS
CELL DIVISION
CHROMOSOMES
DIPLOIDY
ESTERS
GAMETES
GERM CELLS
HETEROCHROMOSOMES
MAMMALS
MEIOSIS
METHYL METHANESULFONATE
MUTAGENS
NON-DISJUNCTION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENYLALANINE
PLOIDY
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SPERMATOCYTES
SPERMATOZOA
SULFONIC ACID ESTERS
VERTEBRATES
VOLES
X CHROMOSOME
Y CHROMOSOME