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Possible mechanism for chemical induction of chromosome aberrations in male meiotic and postmeiotic germ cells of mice

Conference ·
OSTI ID:6035185
The mechanisms by which chemically induced lesions in the chromosomes of mammalian germ cells are actually converted to aberrations and transmitted to progeny are very complex and little understood. An attempt is made to explain how dominant-lethal mutations and heritable translocations are produced from chemical treatment of meiotic and postmeiotic germ cells of male mice.
Research Organization:
Oak Ridge National Lab., TN (USA)
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
6035185
Report Number(s):
CONF-810966-1; ON: DE81031999
Country of Publication:
United States
Language:
English

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Related Subjects

550400 -- Genetics
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CELL CYCLE
CELL DIVISION
CHROMOSOMAL ABERRATIONS
DOMINANT MUTATIONS
GERM CELLS
LETHAL MUTATIONS
MALES
MAMMALS
MICE
MITOSIS
MUTAGENESIS
MUTAGENS
MUTATIONS
RODENTS
VERTEBRATES