Testing of new hypoxic cell sensitizers in vivo

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575826· OSTI ID:6707878

Stone, H B; Sinesi, M S

We tested five agents as potential sensitizers of hypoxic cells in vivo in mammary tumors in C3H mice in comparison with misonidazole. The LD/sub 50/2/ for desmethylmisonidazole was 2.7 mg/g body wt, compared to 1.3 for misonidazole. It was as effective in reducing the TCD/sub 50/ of MDAH-MCa-4 as were equitoxic doses of misonidazole. the LD/sub 50/2/ of SR-2508 was 3.3 mg/g and was as effective a sensitizer as misonidazole. Ro 07-0741 was more toxic, with an LD/sub 50/2/ of 0.6 mg/g, but was as effective as misonidazole at equitoxic doses. NP-1 was also more toxic than misonidazole (LA/sub 50/2/ = 04 mg/g) but was a less effective sensitizer. Rotenone, which causes sensitization by inhibiting cellular respiration, thus increasing the diffusion distance of oxygen, was extremely toxic (LD/sub 50/2/ - 0.003 mg/g), and systemic respiratory inhibition and the radioprotective effects of the dimethyl sulfoxide used to dissolve it rendered it totally ineffective as a sensitizer in vivo.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 6707878
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 91:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANOXIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CESIUM 137
CESIUM ISOTOPES
CHEMICAL PROPERTIES
COMPARATIVE EVALUATIONS
DRUGS
GLANDS
IN VIVO
IRRADIATION
ISOTOPES
LOCAL IRRADIATION
MAMMALS
MAMMARY GLANDS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PERFORMANCE TESTING
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
TESTING
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES