Oncogenic transformations in vitro produced by misonidazole

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Cancer Clin. Trials; (United States)

OSTI ID:5869132

Miller, R C; Hall, E J

The C3H/10T 1/2 cell line, cultured in vitro, was used to study the induction of oncogenic transformations produced by electron affinic compounds which function as hypoxic cell radiosensitizers. The relationship between the incidence of oncogenic transformations and drug concentration was obtained for 3-day exposures to misonidazole. At a concentration of 1 mM, a comparison was made of the carcinogenic potential of misonidazole, desmethylmisonidazole, Ro-07-0741, and SR 2508. Misonidazole and desmethylmisonidazole induced similar frequencies of transformation, while the frequency was doubled for Ro-07-0741 and increased by a factor of 5 for SR 2508. The relative carcinogenicity of the various alternatives to misonidazole is clearly a factor in choosing the next compound to be tested in the clinic.

• Research Organization: Columbia Univ., New York, NY
• OSTI ID: 5869132
• Journal Information: Cancer Clin. Trials; (United States), Journal Name: Cancer Clin. Trials; (United States) Vol. 3; ISSN CCTRD
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
AZOLES
CARCINOGENESIS
CELL CULTURES
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IN VITRO
MISONIDAZOLE
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PHARMACOLOGY
RADIOSENSITIZERS
TOXICITY