Mechanisms for radiation damage in DNA: Comprehensive report for the period, 1 June 1986--31 May 1989

Technical Report · Sat Oct 01 04:00:00 EDT 1988

OSTI ID:6705878

Sevilla, M D

Over the last three years, significant advances have been made in several areas of research resulting in 12 publications in the scientific literature. Some of these were as originally planned in the proposed effort of 1986 and in several cases new laboratory results have resulted in new and profitable directions. The most important recent work has been in the area of the interaction of thiyl radicals and oxygen as well as (DNA) peroxyl radicals with thiols. This work has given a wealth of information not known previously and may have important implications for radiation damage in vivo. This report also outlines some of the main features of the work performed over the past several years. 23 refs.

• Research Organization: Oakland Univ., Rochester, MI (USA)
• DOE Contract Number: FG02-86ER60455
• OSTI ID: 6705878
• Report Number(s): DOE/ER/60455-4; ON: DE89003258
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600 -- Radiation Chemistry
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
AQUEOUS SOLUTIONS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHEMISTRY
CYSTEINE
DISPERSIONS
DNA
DOCUMENT TYPES
DRUGS
ELECTRON SPIN RESONANCE
ELEMENTS
GLUTATHIONE
HYDROXYL RADICALS
HYDROXYLAMINE
KINETICS
LABELLING
MAGNETIC RESONANCE
MIXTURES
NONMETALS
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
PEPTIDES
PH VALUE
POLYPEPTIDES
PROGRESS REPORT
PROTEINS
RADIATION CHEMISTRY
RADICALS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RESONANCE
RESPONSE MODIFYING FACTORS
SOLUTIONS
STRUCTURE-ACTIVITY RELATIONSHIPS
THIOLS
THIYL RADICALS