Spectral dependencies of killing, mutation, and transformation in mammalian cells and their relevance to hazards caused by solar ultraviolet radiation

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Cancer Res.; (United States)

OSTI ID:6705463

Suzuki, F; Han, A; Lankas, G R; Utsumi, H; Elkind, M M

Using germicidal lamps and Westinghouse sunlamps with and without filtration, the effectiveness of ultraviolet and near-ultraviolet light in inducing moleculear and cellular changes was measured. From the results of the study, it is inferred that increasing intensities of short-wavelength ultraviolet light, as would be expected from reductions in stratospheric ozone around the earth, would result in smaller increases in biological action (e.g., skin cancer, compared to current levels of action than would be predicted from an action spectrum completely correspnding to that of a pyrimidine dimer induction spectrum in DNA). (JMT)

• Research Organization: Argonne National Lab., IL
• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 6705463
• Journal Information: Cancer Res.; (United States), Vol. 41
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
RADIOINDUCTION
DNA
MUTATIONS
ONCOGENIC TRANSFORMATIONS
ABSORPTION SPECTRA
DIMERS
NEAR ULTRAVIOLET RADIATION
PYRIMIDINES
SPECTRAL RESPONSE
ULTRAVIOLET RADIATION
AZINES
BIOLOGICAL EFFECTS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
SPECTRA
560121* - Radiation Effects on Cells- External Source- (-1987)