Early results of the screening program for radioprotectors
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Although WR-2721, S-2-(3-aminopropylamino)ethylphosphorotioc acid, is the most widely studied and most effective radioprotective drug at present, it is nevertheless clear from animal studies that it has important shortcomings as the ideal radioprotector in clinical radiotherapy. More effective and less toxic radioprotective drugs are needed. For this reason, a chemical radioprotector screening program has been initiated at the Fox Chase Cancer Center under a contract with the National Cancer Institute. Most of the 20 compounds that have now entered the screening program provide good protection of the mouse hematopoietic system as indicated by 30 day survival following the radiation LD100/30. Administration of a radioprotector dose equal to one half of the maximum tolerated dose (MTD/2) gave hematopoietic dose reduction factors (DRF's) as high as 2.3. No radioprotector appeared to be superior to WR-2721, although four others gave DRF's exceeding 1.8.
- OSTI ID:
- 6704070
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
DOSES
DRUGS
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
LETHAL DOSES
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PHARMACOLOGY
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SCREENING
THIOIC ACIDS
TISSUES
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
DOSES
DRUGS
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
LETHAL DOSES
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PHARMACOLOGY
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SCREENING
THIOIC ACIDS
TISSUES
TOXICITY
VERTEBRATES