Breast cancer: PET imaging of estrogen receptors

Journal Article · Sat Oct 01 04:00:00 EDT 1988 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.169.1.3262228· OSTI ID:6702656

Mintun, M A; Welch, M J; Siegel, B A; Mathias, C J; Brodack, J W; McGuire, A H; Katzenellenbogen, J A

Thirteen patients with primary breast masses were studied with positron emission tomography (PET) and 16 alpha-(fluorine-18)-fluoroestradiol-17 beta. PET images demonstrated uptake of the labeled estrogen analog at sites of primary carcinomas and in several foci of axillary lymph node metastases, as well as in one distant metastatic site. There was excellent correlation between uptake within the primary tumor measured on the PET images and the tumor estrogen-receptor concentration measured in vitro after excision (r = .96). This technique may provide an in vivo method of assessing estrogen receptors in primary and metastatic breast cancers and thus guide management of this disease with antiestrogen chemotherapy.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO (USA)
• OSTI ID: 6702656
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 169:1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
ESTRADIOL
ESTRANES
ESTROGENS
FLUORINE 18
FLUORINE ISOTOPES
GLANDS
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MAMMARY GLANDS
MEMBRANE PROTEINS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
RADIOISOTOPES
RECEPTORS
STEROID HORMONES
STEROIDS
TOMOGRAPHY