PET Imaging Agents (FES, FFNP, and FDHT) for Estrogen, Androgen, and Progesterone Receptors to Improve Management of Breast and Prostate Cancers by Functional Imaging

Katzenellenbogen, John A.

doi:10.3390/cancers12082020

PET Imaging Agents (FES, FFNP, and FDHT) for Estrogen, Androgen, and Progesterone Receptors to Improve Management of Breast and Prostate Cancers by Functional Imaging

Journal Article · Thu Jul 23 00:00:00 EDT 2020 · Cancers (Basel)

DOI:https://doi.org/10.3390/cancers12082020· OSTI ID:1800647

Katzenellenbogen, John A. ^[1]

Univ. of Illinois at Urbana-Champaign, IL (United States). Cancer Center at Illinois. Dept. of Chemistry; OSTI

Many breast and prostate cancers are driven by the action of steroid hormones on their cognate receptors in primary tumors and in metastases, and endocrine therapies that inhibit hormone production or block the action of these receptors provide clinical benefit to many but not all of these cancer patients. Because it is difficult to predict which individuals will be helped by endocrine therapies and which will not, positron emission tomography (PET) imaging of estrogen receptor (ER) and progesterone receptor (PgR) in breast cancer, and androgen receptor (AR) in prostate cancer can provide useful, often functional, information on the likelihood of endocrine therapy response in individual patients. This review covers our development of three PET imaging agents, 16α-[¹⁸F]fluoroestradiol (FES) for ER, 21-[¹⁸F]fluoro-furanyl-nor-progesterone (FFNP) for PgR, and 16β-[¹⁸F]fluoro-5α-dihydrotestosterone (FDHT) for AR, and the evolution of their clinical use. For these agents, the pathway from concept through development tracks with an emerging understanding of critical performance criteria that is needed for successful PET imaging of these low-abundance receptor targets. Progress in the ongoing evaluation of what they can add to the clinical management of breast and prostate cancers reflects our increased understanding of these diseases and of optimal strategies for predicting the success of clinical endocrine therapies.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: FG02-86ER60401

OSTI ID:: 1800647

Journal Information:: Cancers (Basel), Journal Name: Cancers (Basel) Journal Issue: 8 Vol. 12; ISSN CANCCT; ISSN 2072-6694

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

References (158)

Diethylstilbestrol: Recommended Dosages for Different Categories of Breast Cancer Patients: Report of the Cooperative Breast Cancer Group Carter, Anne C. JAMA, Vol. 237, Issue 19 https://doi.org/10.1001/jama.1977.03270460065023	journal	May 1977
Tamoxifen Flare in Advanced Breast Cancer Plotkin, David JAMA: The Journal of the American Medical Association, Vol. 240, Issue 24 https://doi.org/10.1001/jama.1978.03290240044022	journal	December 1978
Lower-Dose vs High-Dose Oral Estradiol Therapy of Hormone Receptor–Positive, Aromatase Inhibitor–Resistant Advanced Breast Cancer: A Phase 2 Randomized Study Ellis, Matthew J.; Gao, Feng; Dehdashti, Farrokh JAMA, Vol. 302, Issue 7 https://doi.org/10.1001/jama.2009.1204	journal	August 2009
Clinicopathological Characteristics and Breast Cancer–Specific Survival of Patients With Single Hormone Receptor–Positive Breast Cancer Li, Yunhai; Yang, Dejuan; Yin, Xuedong JAMA Network Open, Vol. 3, Issue 1 https://doi.org/10.1001/jamanetworkopen.2019.18160	journal	January 2020
Positron Emission Tomography/Computed Tomography–Based Assessments of Androgen Receptor Expression and Glycolytic Activity as a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer Fox, Josef J.; Gavane, Somali C.; Blanc-Autran, Estelle JAMA Oncology, Vol. 4, Issue 2 https://doi.org/10.1001/jamaoncol.2017.3588	journal	February 2018
Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial Sparano, Joseph A.; Gray, Robert J.; Makower, Della F. JAMA Oncology, Vol. 6, Issue 3 https://doi.org/10.1001/jamaoncol.2019.4794	journal	March 2020
Current status of estrogen and progesterone receptors in breast cancer McGuire, W. L.; Horwitz, K. B.; Pearson, O. H. Cancer, Vol. 39, Issue 6 https://doi.org/10.1002/1097-0142(197706)39:6<2934::AID-CNCR2820390680>3.0.CO;2-P	journal	June 1977
Clinical pharmacology of tamoxifen in patients with breast cancer: Correlation with clinical data Fabian, Carol; Sternson, Larry; El-serafi, Moustafa Cancer, Vol. 48, Issue 4 https://doi.org/10.1002/1097-0142(19810815)48:4<876::AID-CNCR2820480403>3.0.CO;2-Q	journal	August 1981
Steroid-hormone receptors in breast cancer Wittliff, James L. Cancer, Vol. 53, Issue S3 https://doi.org/10.1002/1097-0142(19840201)53:3+<630::AID-CNCR2820531308>3.0.CO;2-3	journal	February 1984
Advances in medical imaging for cancer diagnosis and treatment Wagner, Henry N.; Conti, Peter S. Cancer, Vol. 67, Issue S4 https://doi.org/10.1002/1097-0142(19910215)67:4+<1121::AID-CNCR2820671504>3.0.CO;2-U	journal	February 1991
Meta-analysis of the impact of progesterone receptor status on oncological outcomes in oestrogen receptor-positive breast cancer Boland, M. R.; Ryan, É J.; Dunne, E. British Journal of Surgery, Vol. 107, Issue 1 https://doi.org/10.1002/bjs.11347	journal	November 2019
Teflon radiolysis as the major source of carrier in fluorine-18 Berridge, M. S.; Apana, S. M.; Hersh, J. M. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 52, Issue 13 https://doi.org/10.1002/jlcr.1672	journal	November 2009
Alternative synthesis for the preparation of 16 α -[ ¹⁸ F]fluoroestradiol: Alternative synthesis for the preparation of [ ¹⁸ F]FES Kil, Hee Seup; Cho, Han Yang; Lee, Sang Ju Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 56, Issue 12 https://doi.org/10.1002/jlcr.3076	journal	July 2013
Optimization of the preparation of fluorine-18-labeled steroid receptor ligands 16alpha-[ ¹⁸ F]fluoroestradiol (FES), [ ¹⁸ F]fluoro furanyl norprogesterone (FFNP), and 16beta-[ ¹⁸ F]fluoro-5alpha-dihydrotestosterone (FDHT) as radiopharmaceuticals: Optimization of FES, FFNP, and FDHT as radiopharmaceuticals Zhou, Dong; Lin, Mai; Yasui, Norio Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 57, Issue 5 https://doi.org/10.1002/jlcr.3191	journal	February 2014
Rapid synthesis of [ ¹⁸ F]fluoroestradiol: remarkable advantage of microwaving over conventional heating: Shi et al. Shi, Jianfeng; Afari, George; Bhattacharyya, Sibaprasad Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 57, Issue 14 https://doi.org/10.1002/jlcr.3248	journal	December 2014
Synthesis of 16α-ethyl-21-hydroxy-19-norpregn-4-ene-3,20-dione (Org 2058) Zeelen, F. J.; van den Broek, A. J. Recueil des Travaux Chimiques des Pays-Bas, Vol. 104, Issue 9 https://doi.org/10.1002/recl.19851040907	journal	January 1985
The uptake of radioiodinated 5?-dihydrotestosterone by the prostate of intact and castrated rats Tarle, M.; Padovan, R.; Spaventi, ?. European Journal of Nuclear Medicine, Vol. 6, Issue 2 https://doi.org/10.1007/BF00253718	journal	February 1981
Investigations into the use of 77Br labelled 5?-dihydrotestosterone for scanning the prostate Ghanadian, R.; Waters, S. L.; Chisholm, G. D. European Journal of Nuclear Medicine, Vol. 2, Issue 3 https://doi.org/10.1007/BF00257273	journal	January 1977
Positron tomographic assessment of androgen receptors in prostatic carcinoma Dehdashti, Farrokh; Picus, Joel; Michalski, Jeff M. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 32, Issue 3 https://doi.org/10.1007/s00259-005-1764-5	journal	February 2005
Pearls and pitfalls in clinical interpretation of prostate-specific membrane antigen (PSMA)-targeted PET imaging Sheikhbahaei, Sara; Afshar-Oromieh, Ali; Eiber, Matthias European Journal of Nuclear Medicine and Molecular Imaging, Vol. 44, Issue 12 https://doi.org/10.1007/s00259-017-3780-7	journal	August 2017
Positron emission tomographic assessment of ?metabolic flare" to predict response of metastatic breast cancer to antiestrogen therapy Dehdashti, Farrokh; Flanagan, Fidelma L.; Mortimer, Joanne E. European Journal of Nuclear Medicine and Molecular Imaging, Vol. 26, Issue 1 https://doi.org/10.1007/s002590050359	journal	January 1999
Phase II trial of neoadjuvant letrozole and lapatinib in Asian postmenopausal women with estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2)-positive breast cancer [Neo-ALL-IN]: Highlighting the TILs, ER expressional change after neoadjuvant treatment, and FES-PET as potential significant biomarkers Park, Ji Hyun; Kang, Myung Joo; Ahn, Jin-Hee Cancer Chemotherapy and Pharmacology, Vol. 78, Issue 4 https://doi.org/10.1007/s00280-016-3107-6	journal	August 2016
PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer Dehdashti, Farrokh; Mortimer, Joanne E.; Trinkaus, Kathryn Breast Cancer Research and Treatment, Vol. 113, Issue 3 https://doi.org/10.1007/s10549-008-9953-0	journal	March 2008
Assessment of the Novel Estrogen Receptor PET Tracer 4-Fluoro-11β-methoxy-16α-[18F]fluoroestradiol (4FMFES) by PET Imaging in a Breast Cancer Murine Model Paquette, Michel; Phoenix, Serge; Ouellet, René Molecular Imaging and Biology, Vol. 15, Issue 5 https://doi.org/10.1007/s11307-013-0638-7	journal	April 2013
The synthesis of 77Br-labelled 5α-dihydrotestosterone and a comparison of its distribution in rats with 77Br-bromide Eakins, M. N.; Waters, S. L. The International Journal of Applied Radiation and Isotopes, Vol. 30, Issue 11 https://doi.org/10.1016/0020-708X(79)90112-1	journal	November 1979
Methodology for the synthesis and specific activity determination of 16α-[77Br]-Bromoestradiol-17 β and 16α-[77Br]-11 β-methoxyestradiol-17 β, Two estrogen receptor-binding radiopharmaceuticals Senderoff, Stephen G.; McElvany, Karen D.; Carlson, Kathyrn E. The International Journal of Applied Radiation and Isotopes, Vol. 33, Issue 7 https://doi.org/10.1016/0020-708X(82)90010-2	journal	July 1982
Synthesis of 16α-[125I]iodo-5α-dihydrotestosterone and evaluation of its affinity for the androgen receptor Hoyte, R. M.; Rosner, W.; Hochberg, R. B. Journal of Steroid Biochemistry, Vol. 16, Issue 5 https://doi.org/10.1016/0022-4731(82)90097-8	journal	May 1982
Factors affecting the target site uptake selectivity of estrogen radiopharmaceuticals: Serum binding and endogenous estrogens McElvany, Karen D.; Carlson, Kathryn E.; Katzenellenbogen, John A. Journal of Steroid Biochemistry, Vol. 18, Issue 6 https://doi.org/10.1016/0022-4731(83)90240-6	journal	June 1983
Estrogen receptor binding affinity and uterotrophic activity of triphenylhaloethylenes DeSombre, Eugene R.; Mease, Ronnie C.; Sanghavl, Jigi Journal of Steroid Biochemistry, Vol. 29, Issue 6 https://doi.org/10.1016/0022-4731(88)90155-0	journal	June 1988
Regulation of progesterone receptor mRNA by oestradiol and antioestrogens in breast cancer cell lines May, Felicity E. B.; Johnson, Michael D.; Wiseman, Lynda R. Journal of Steroid Biochemistry, Vol. 33, Issue 6 https://doi.org/10.1016/0022-4731(89)90406-8	journal	December 1989
The synthesis and testing of E-17α -(2-iodovinyl)-5α -dihydrotestosterone and Z-17α -(2-iodovinyl)-5α -dihydrotestosterone as γ-emitting ligands for the androgen receptor Hoyte, Robert M.; MacLusky, Neil J.; Hochberg, Richard B. Journal of Steroid Biochemistry, Vol. 36, Issue 1-2 https://doi.org/10.1016/0022-4731(90)90122-9	journal	June 1990
A comparative study of the selectivity and efficiency of target tissue uptake of five tritium-labeled androgens in the rat Carlson, Kathryn E.; Katzenellenbogen, John A. Journal of Steroid Biochemistry, Vol. 36, Issue 6 https://doi.org/10.1016/0022-4731(90)90172-O	journal	August 1990
(2∗, 3∗)-1- [18fluoro-2, 3-bis (4-hydroxyphenyl) pentane ([18F]fluoronorhexestrol), A positron-emitting estrogen that shows highly-selective, receptor-mediated uptake by target tissues in vivo Landvatter, Scott W.; Kiesewetter, Dale O.; Kilbourn, Michael R. Life Sciences, Vol. 33, Issue 19 https://doi.org/10.1016/0024-3205(83)90678-1	journal	November 1983
Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: Potential agents for imaging the dopamine receptor Welch, Michael J.; Kilbourn, Michael R.; Mathias, Carla J. Life Sciences, Vol. 33, Issue 17 https://doi.org/10.1016/0024-3205(83)90725-7	journal	October 1983
Synthesis of fluorine-18 labeled 21-fluoroprogesterone Spitznagle, Larry A.; Marino, Carol A. Steroids, Vol. 30, Issue 4 https://doi.org/10.1016/0039-128X(77)90091-5	journal	October 1977
Synthesis of C-6 fluoroandrogens: Evaluation of ligands for tumor receptor imaging Choe, Yearn Seong; Katzenellenbogen, John A. Steroids, Vol. 60, Issue 5 https://doi.org/10.1016/0039-128X(95)00009-F	journal	May 1995
Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare Reddel, Roger R.; Sutherland, Robert L. European Journal of Cancer and Clinical Oncology, Vol. 20, Issue 11 https://doi.org/10.1016/0277-5379(84)90062-2	journal	November 1984
Preclinical evaluation of a positron emitting progestin ([18F]fluoro-16α-methyl-19-norprogesterone) for imaging progesterone receptor positive tumours with positron emission tomography Verhagen, A.; Luurtsema, G.; Pesser, J. W. Cancer Letters, Vol. 59, Issue 2 https://doi.org/10.1016/0304-3835(91)90176-I	journal	August 1991
Characterization of the uptake of 16α-([18F]fluoro)-17β-estradiol in DMBA-induced mammary tumors Mathias, Carla J.; Welch, Michael J.; Katzenellenbogen, John A. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 14, Issue 1 https://doi.org/10.1016/0883-2897(87)90156-5	journal	January 1987
Uptake of three [3H]progestins by target tissues in vivo: Implications for the design of diagnostic imaging agents Carlson, Kathryn E.; Brandes, Stephanie J.; Pomper, Martin G. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 15, Issue 4 https://doi.org/10.1016/0883-2897(88)90010-4	journal	January 1988
Fundamental considerations in the design of fluorine-18 labeled progestins and androgens as imaging agents for receptor-positive tumors of the breast and prostate Brandes, Stephanie J.; Katzenellenbogen, John A. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 15, Issue 1 https://doi.org/10.1016/0883-2897(88)90162-6	journal	January 1988
Target tissue uptake selectivity of three fluorine-substituted progestins: Potential imaging agents for receptor-positive breast tumors Pomper, Martin G.; Pinney, Kevin G.; Carlson, Kathryn E. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 17, Issue 3 https://doi.org/10.1016/0883-2897(90)90058-9	journal	January 1990
Fluorine-substituted corticosteroids: Synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain Pomper, Martin G.; Kochanny, Monica J.; Thieme, Andrea M. International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 19, Issue 4 https://doi.org/10.1016/0883-2897(92)90161-Q	journal	May 1992
Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor Teutsch, G.; Goubet, F.; Battmann, T. The Journal of Steroid Biochemistry and Molecular Biology, Vol. 48, Issue 1 https://doi.org/10.1016/0960-0760(94)90257-7	journal	January 1994
Synthesis of (17α, 20E/Z)Iodovinyl testosterone and 19-nortestosterone derivatives as potential radioligands for androgen and progesterone receptors Ali, Hasrat; Rousseau, J.; van Lier, J. E. The Journal of Steroid Biochemistry and Molecular Biology, Vol. 49, Issue 1 https://doi.org/10.1016/0960-0760(94)90296-8	journal	May 1994
Titration of the in vivo uptake of 16α-[18F]fluoroestradiol by target tissues in the rat: Competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development Katzenellenbogen, John A.; Mathias, Carla J.; Vanbrocklin, Henry F. Nuclear Medicine and Biology, Vol. 20, Issue 6 https://doi.org/10.1016/0969-8051(93)90160-V	journal	August 1993
Titration of the in vivo uptake of 16α-[18F]fluoroestradiol by target tissues in the rat: Competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development Katzenellenbogen, John A.; Mathias, Carla J.; Vanbrocklin, Henry F. Nuclear Medicine and Biology, Vol. 20, Issue 6 https://doi.org/10.1016/0969-8051(93)90160-v	journal	August 1993
Metabolism of a [18F]fluorine labeled progestin (21 -[18F]fluoro-16α -ethyl-19-norprogesterone) in humans: a clue for future investigations Verhagen, A.; Studeny, M.; Luurtsema, G. Nuclear Medicine and Biology, Vol. 21, Issue 7 https://doi.org/10.1016/0969-8051(94)90083-3	journal	October 1994
Oxohexestrol derivatives labeled with fluorine-18. Synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents Bergmann, Kathryn E.; Landvatter, Scott W.; Rocque, Pamela G. Nuclear Medicine and Biology, Vol. 21, Issue 1 https://doi.org/10.1016/0969-8051(94)90126-0	journal	January 1994
Comparison of the distribution of radioiodinated di- and tri-hydroxyphenylethylene estrogens in the immature female rat Desombre, Eugene R.; Pribish, James; Hughes, Alun Nuclear Medicine and Biology, Vol. 22, Issue 5 https://doi.org/10.1016/0969-8051(95)00002-F	journal	July 1995
Iodinated and fluorinated steroid 2′-aryl-[3,2-c] pyrazoles as potential glucocorticoid receptor imaging agents Hoyte, Robert M.; Labaree, David C.; Fede, Jean-Marie Steroids, Vol. 63, Issue 11 https://doi.org/10.1016/S0039-128X(98)00069-5	journal	November 1998
Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study Scher, Howard I.; Beer, Tomasz M.; Higano, Celestia S. The Lancet, Vol. 375, Issue 9724 https://doi.org/10.1016/S0140-6736(10)60172-9	journal	April 2010
Tamoxifen in advanced breast cancer Mouridsen, Henning; Palshof, Torben; Patterson, John Cancer Treatment Reviews, Vol. 5, Issue 3 https://doi.org/10.1016/S0305-7372(78)80017-6	journal	September 1978
Comparison of animal models for the evaluation of radiolabeled androgens Downer, Joanna B.; Jones, Lynne A.; Engelbach, John A. Nuclear Medicine and Biology, Vol. 28, Issue 6 https://doi.org/10.1016/S0969-8051(01)00229-3	journal	August 2001
The use of 3-methoxymethyl-16β, 17β-epiestriol-O-cyclic sulfone as the precursor in the synthesis of F-18 16α-fluoroestradiol Lim, J. L.; Zheng, Lei; Berridge, M. S. Nuclear Medicine and Biology, Vol. 23, Issue 7 https://doi.org/10.1016/S0969-8051(96)00126-6	journal	October 1996
New iodinated progestins as potential ligands for progesterone receptor imaging in breast cancer. part 1: synthesis and in vitro pharmacological characterization van den Bos, Jan C.; Rijks, Leonie J. M.; van Doremalen, Peter A. P. M. Nuclear Medicine and Biology, Vol. 25, Issue 8 https://doi.org/10.1016/S0969-8051(98)00041-9	journal	November 1998
New iodinated progestins as potential ligands for progesterone receptor imaging in breast cancer. part 2: in vivo pharmacological characterization Rijks, Leonie J. M.; van den Bos, Jan C.; van Doremalen, Peter A. P. M. Nuclear Medicine and Biology, Vol. 25, Issue 8 https://doi.org/10.1016/S0969-8051(98)00042-0	journal	November 1998
Comparative breast tumor imaging and comparative in vitro metabolism of 16α-[18F]Fluoroestradiol-17β and 16β-[18f]fluoromoxestrol in isolated hepatocytes Jonson, Stephanie D.; Bonasera, Thomas A.; Dehdashti, Farrokh Nuclear Medicine and Biology, Vol. 26, Issue 1 https://doi.org/10.1016/S0969-8051(98)00079-1	journal	January 1999
PET imaging of oestrogen receptors in patients with breast cancer van Kruchten, Michel; de Vries, Elisabeth G. E.; Brown, Myles The Lancet Oncology, Vol. 14, Issue 11 https://doi.org/10.1016/S1470-2045(13)70292-4	journal	October 2013
Radiosynthesis and radiopharmacological evaluation of [N-methyl-11C]Org 34850 as a glucocorticoid receptor (GR)-binding radiotracer Wuest, Frank; Kniess, Torsten; Henry, Brian Applied Radiation and Isotopes, Vol. 67, Issue 2 https://doi.org/10.1016/j.apradiso.2008.10.014	journal	February 2009
Automated SPE-based synthesis of 16α-[18F]fluoroestradiol without HPLC purification step Fedorova, Olga; Nikolaeva, Viktoria; Krasikova, Raisa Applied Radiation and Isotopes, Vol. 141 https://doi.org/10.1016/j.apradiso.2018.08.007	journal	November 2018
The influence of glucocorticoid signaling on tumor progression Volden, Paul A.; Conzen, Suzanne D. Brain, Behavior, and Immunity, Vol. 30 https://doi.org/10.1016/j.bbi.2012.10.022	journal	March 2013
Estrogen receptor 1 and progesterone receptor are distinct biomarkers and prognostic factors in estrogen receptor-positive breast cancer: Evidence from a bioinformatic analysis Wu, Jun-Rong; Zhao, Yang; Zhou, Xiao-Ping Biomedicine & Pharmacotherapy, Vol. 121 https://doi.org/10.1016/j.biopha.2019.109647	journal	January 2020
A review of the clinical efficacy and safety of 5α-reductase inhibitors for the enlarged prostate Naslund, Michael J.; Miner, Martin Clinical Therapeutics, Vol. 29, Issue 1 https://doi.org/10.1016/j.clinthera.2007.01.018	journal	January 2007
Clinical Potential of Estrogen and Progesterone Receptor Imaging Linden, Hannah M.; Peterson, Lanell M.; Fowler, Amy M. PET Clinics, Vol. 13, Issue 3 https://doi.org/10.1016/j.cpet.2018.02.005	journal	July 2018
Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid Pippione, Agnese Chiara; Carnovale, Irene Maria; Bonanni, Davide European Journal of Medicinal Chemistry, Vol. 150 https://doi.org/10.1016/j.ejmech.2018.03.040	journal	April 2018
Impact of 68 Ga-PSMA PET on the Management of Patients with Prostate Cancer: A Systematic Review and Meta-analysis Han, Sangwon; Woo, Sungmin; Kim, Yeon Joo European Urology, Vol. 74, Issue 2 https://doi.org/10.1016/j.eururo.2018.03.030	journal	August 2018
Synthesis and biological evaluation of a fluorine-18-labeled nonsteroidal androgen receptor antagonist, N-(3-[18F]fluoro-4-nitronaphthyl)-cis-5-norbornene-endo-2,3-dicarboxylic imide Parent, Ephraim E.; Dence, Carmen S.; Sharp, Terry L. Nuclear Medicine and Biology, Vol. 33, Issue 5 https://doi.org/10.1016/j.nucmedbio.2006.04.003	journal	July 2006
Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide Parent, Ephraim E.; Jenks, Carl; Sharp, Terry Nuclear Medicine and Biology, Vol. 33, Issue 6 https://doi.org/10.1016/j.nucmedbio.2006.05.009	journal	August 2006
Factors influencing the uptake of 18F-fluoroestradiol in patients with estrogen receptor positive breast cancer Peterson, Lanell M.; Kurland, Brenda F.; Link, Jeanne M. Nuclear Medicine and Biology, Vol. 38, Issue 7 https://doi.org/10.1016/j.nucmedbio.2011.03.002	journal	October 2011
The quest for improving the management of breast cancer by functional imaging: The discovery and development of 16α-[18F]fluoroestradiol (FES), a PET radiotracer for the estrogen receptor, a historical review Katzenellenbogen, John A. Nuclear Medicine and Biology, Vol. 92 https://doi.org/10.1016/j.nucmedbio.2020.02.007	journal	January 2021
Concepts for design and analysis of receptor radiopharmaceuticals: The Receptor-Binding Radiotracers series of meetings provided the foundation Krohn, Kenneth A.; Vera, David R. Nuclear Medicine and Biology, Vol. 92 https://doi.org/10.1016/j.nucmedbio.2020.03.002	journal	January 2021
Synthesis of the 7α-cyano-(17α,20E/Z)-[125I]iodovinyl-19-nortestosterones: potential radioligands for androgen and progesterone receptors Ali, Hasrat; Rousseau, Jacques; Ahmed, Naseem Steroids, Vol. 68, Issue 14 https://doi.org/10.1016/j.steroids.2003.08.011	journal	December 2003
Expeditious synthesis of steroids containing a 2-methylsulfanyl-acetyl side chain as potential glucocorticoid receptor imaging agents Wuest, Frank; Carlson, Kathryn E.; Katzenellenbogen, John A. Steroids, Vol. 73, Issue 1 https://doi.org/10.1016/j.steroids.2007.08.013	journal	January 2008
Synthesis and evaluation of 2-halogenated-1,1-bis(4-hydroxyphenyl)-2-(3-hydroxyphenyl)-ethylenes as potential estrogen receptor-targeted radiodiagnostic and radiotherapeutic agents Hanson, Robert N.; Tongcharoensirikul, Pakamas; Barnsley, Kelton Steroids, Vol. 96 https://doi.org/10.1016/j.steroids.2015.01.013	journal	April 2015
Development of [F-18]Fluorine-Substituted Tanaproget as a Progesterone Receptor Imaging Agent for Positron Emission Tomography Lee, Jae Hak; Zhou, Hai-bing; Dence, Carmen S. Bioconjugate Chemistry, Vol. 21, Issue 6 https://doi.org/10.1021/bc1001054	journal	May 2010
Iodohexestrols. I. Synthesis and photoreactivity of iodinated hexestrol derivatives Katzenellenbogen, John A.; Hsiung, Hansen M. Biochemistry, Vol. 14, Issue 8 https://doi.org/10.1021/bi00679a028	journal	April 1975
Iodohexestrols. II. Characterization of the binding and estrogenic activity of iodinated hexestrol derivatives, in vitro and in vivo Katzenellenbogen, John A.; Hsiung, Hansen M.; Carlson, Kathryn E. Biochemistry, Vol. 14, Issue 8 https://doi.org/10.1021/bi00679a029	journal	April 1975
Photoaffinity labels for estrogen binding proteins of rat uterus Katzenellenbogen, John A.; Johnson, Howard J.; Myers, Harvey N. Biochemistry, Vol. 12, Issue 21 https://doi.org/10.1021/bi00745a010	journal	October 1973
Fluorine-18-labeled progestin 16.alpha.,17.alpha.-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity Buckman, Brad O.; Bonasera, Thomas A.; Kirschbaum, Karen S. Journal of Medicinal Chemistry, Vol. 38, Issue 2 https://doi.org/10.1021/jm00002a014	journal	January 1995
Synthesis of 11.beta.-[18F]Fluoro-5.alpha.-dihydrotestosterone and 11.beta.-[18F]Fluoro-19-nor-5.alpha.-dihydrotestosterone: Preparation via Halofluorination-Reduction, Receptor Binding, and Tissue Distribution Choe, Yearn Seong; Lidstroem, Pelle J.; Chi, Dae Yoon Journal of Medicinal Chemistry, Vol. 38, Issue 5 https://doi.org/10.1021/jm00005a009	journal	March 1995
Progestin 16.alpha.,17.alpha.-dioxolane ketals as molecular probes for the progesterone receptor: synthesis, binding affinity, and photochemical evaluation Kym, Philip R.; Carlson, Kathryn E.; Katzenellenbogen, John A. Journal of Medicinal Chemistry, Vol. 36, Issue 9 https://doi.org/10.1021/jm00061a001	journal	April 1993
Fluorine-18 labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors Kochanny, Monica J.; VanBrocklin, Henry F.; Kym, Philip R. Journal of Medicinal Chemistry, Vol. 36, Issue 9 https://doi.org/10.1021/jm00061a002	journal	April 1993
Synthesis of high-affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography Liu, Aijun; Carlson, Kathryn E.; Katzenellenbogen, John A. Journal of Medicinal Chemistry, Vol. 35, Issue 11 https://doi.org/10.1021/jm00089a024	journal	May 1992
A potential radioiodinated ligand for androgen receptor: 7.alpha.-methyl-17.alpha.-[2'-(E)-iodovinyl]-19-nortestosterone Salman, Mohammad; Chamness, Gary C. Journal of Medicinal Chemistry, Vol. 34, Issue 3 https://doi.org/10.1021/jm00107a021	journal	March 1991
Synthesis and evaluation of potential radioligands for the progesterone receptor Hoyte, R. M.; Rosner, W.; Johnson, I. S. Journal of Medicinal Chemistry, Vol. 28, Issue 11 https://doi.org/10.1021/jm00149a027	journal	November 1985
11.beta.-Methoxy-, 11.beta.-ethyl, and 17.alpha.-ethynyl-substituted 16.alpha.-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity Pomper, Martin G.; VanBrocklin, Henry; Thieme, Andrea M. Journal of Medicinal Chemistry, Vol. 33, Issue 12 https://doi.org/10.1021/jm00174a009	journal	December 1990
Estrogen receptor-based imaging agents. 1. Synthesis and receptor binding affinity of some aromatic and D-ring halogenated estrogens Heiman, Daniel F.; Senderoff, Stephen G.; Katzenellenbogen, John A. Journal of Medicinal Chemistry, Vol. 23, Issue 9 https://doi.org/10.1021/jm00183a007	journal	September 1980
Nonsteroidal estrogens: synthesis and estrogen receptor binding affinity of derivatives of (3R,4S)-3,4-bis(4-hydroxyphenyl)hexane (hexestrol) and (2R,3S)-2,3-bis(4-hydroxyphenyl)pentane (norhexestrol) functionalized on the side chain Landvatter, Scott W.; Katzenellenbogen, J. A. Journal of Medicinal Chemistry, Vol. 25, Issue 11 https://doi.org/10.1021/jm00353a006	journal	November 1982
21-[18F]fluoro-16.alpha.-ethyl-19-norprogesterone. Synthesis and target tissue selective uptake of a progestin receptor-based radiotracer for positron emission tomography Pomper, Martin G.; Katzenellenbogen, John A.; Welch, Michael J. Journal of Medicinal Chemistry, Vol. 31, Issue 7 https://doi.org/10.1021/jm00402a019	journal	July 1988
Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[ d ][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget ^# Fensome, Andrew; Bender, Reinhold; Chopra, Rajiv Journal of Medicinal Chemistry, Vol. 48, Issue 16 https://doi.org/10.1021/jm050358b	journal	August 2005
Bromine- and Iodine-Substituted 16α,17α-Dioxolane Progestins for Breast Tumor Imaging and Radiotherapy: Synthesis and Receptor Binding Affinity Zhou, Dong; Carlson, Kathryn E.; Katzenellenbogen, John A. Journal of Medicinal Chemistry, Vol. 49, Issue 15 https://doi.org/10.1021/jm060348q	journal	June 2006
Synthesis and Biological Evaluation of [ ¹⁸ F]Bicalutamide, 4-[ ⁷⁶ Br]Bromobicalutamide, and 4-[ ⁷⁶ Br]Bromo-thiobicalutamide as Non-Steroidal Androgens for Prostate Cancer Imaging Parent, Ephraim E.; Dence, Carmen S.; Jenks, Carl Journal of Medicinal Chemistry, Vol. 50, Issue 5 https://doi.org/10.1021/jm060847r	journal	March 2007
Imaging Progesterone Receptor in Breast Tumors: Synthesis and Receptor Binding Affinity of Fluoroalkyl-Substituted Analogues of Tanaproget Zhou, Hai-Bing; Lee, Jae Hak; Mayne, Christopher G. Journal of Medicinal Chemistry, Vol. 53, Issue 8 https://doi.org/10.1021/jm100052k	journal	April 2010
Synthesis of 16-fluoroestrogens by unusually facile fluoride ion displacement reactions: prospects for the preparation of fluorine-18 labeled estrogens Kiesewetter, Dale O.; Katzenellenbogen, John A.; Kilbourn, Michael R. The Journal of Organic Chemistry, Vol. 49, Issue 25 https://doi.org/10.1021/jo00199a031	journal	December 1984
High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy Lønning, Per E.; Taylor, Paul D.; Anker, Gun Breast Cancer Research and Treatment, Vol. 67, Issue 2 https://doi.org/10.1023/A:1010619225209	journal	May 2001
Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study Purdie, C. A.; Quinlan, P.; Jordan, L. B. British Journal of Cancer, Vol. 110, Issue 3 https://doi.org/10.1038/bjc.2013.756	journal	December 2013
The value of PET/CT with FES or FDG tracers in metastatic breast cancer: a computer simulation study in ER-positive patients Koleva-Kolarova, R. G.; Greuter, M. J. W.; van Kruchten, M. British Journal of Cancer, Vol. 112, Issue 10 https://doi.org/10.1038/bjc.2015.138	journal	April 2015
Synthesis and pre-clinical evaluation of a [ ¹⁸ F]fluoromethyl-tanaproget derivative for imaging of progesterone receptor expression Merchant, Shairoz; Allott, Louis; Carroll, Laurence RSC Advances, Vol. 6, Issue 62 https://doi.org/10.1039/C6RA07404A	journal	January 2016
Randomized Clinical Trial of Diethylstilbestrol versus Tamoxifen in Postmenopausal Women with Advanced Breast Cancer Ingle, James N.; Ahmann, David L.; Green, Stephanie J. New England Journal of Medicine, Vol. 304, Issue 1 https://doi.org/10.1056/NEJM198101013040104	journal	January 1981
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart New England Journal of Medicine, Vol. 366, Issue 10 https://doi.org/10.1056/NEJMoa1113205	journal	March 2012
Interaction of 16 alpha-[125I]iodo-estradiol with estrogen receptor and other steroid-binding proteins. Hochberg, R. B.; Rosner, W. Proceedings of the National Academy of Sciences, Vol. 77, Issue 1 https://doi.org/10.1073/pnas.77.1.328	journal	January 1980
Metabolism of anabolic androgenic steroids Schänzer, W. Clinical Chemistry, Vol. 42, Issue 7 https://doi.org/10.1093/clinchem/42.7.1001	journal	July 1996
18f-Labeled 3-Deoxy-3-Fluoro-Glucose: Synthesis and Preliminary Biodistribution data Tewson, T. J.; Welch, M. J.; Raichle, M. E. Journal of Computer Assisted Tomography, Vol. 3, Issue 2 https://doi.org/10.1097/00004728-197904000-00060	journal	January 1979
16α-[77Br]BROMOESTRADIOL-17β: A HIGH-SPECIFIC-ACTIVITY, GAMMA-EMITTING TRACER WITH UPTAKE IN RAT UTERUS AND INDUCED MAMMARY TUMORS Katzenellenbogen, J. A.; Senderoff, S. G.; McElvany, K. D. Journal of Computer Assisted Tomography, Vol. 5, Issue 3 https://doi.org/10.1097/00004728-198106000-00058	journal	January 1981
Fully automatic synthesis of [18F]FES for reporter gene hERL expression imaging Liang, Sheng; Lan, Xiaoli; Zhang, Yongxue Nuclear Medicine Communications, Vol. 33, Issue 1 https://doi.org/10.1097/MNM.0b013e32834d3b92	journal	January 2012
Recommendations and Technical Aspects of 16α-[18F]Fluoro-17β-Estradiol PET to Image the Estrogen Receptor In Vivo: The Groningen Experience Venema, Clasina M.; Apollonio, Giulia; Hospers, Geke A. P. Clinical Nuclear Medicine, Vol. 41, Issue 11 https://doi.org/10.1097/RLU.0000000000001347	journal	January 2016
Predicting response to endocrine therapy in human breast cancer: a hypothesis Horowitz, K.; McGuire, W. Science, Vol. 189, Issue 4204 https://doi.org/10.1126/science.168640	journal	August 1975
Influence of Synthetic Oestrogens on Advanced Malignant Disease Haddow, A.; Watkinson, J. M.; Paterson, E. BMJ, Vol. 2, Issue 4368 https://doi.org/10.1136/bmj.2.4368.393	journal	September 1944
Ovarian ablation in breast cancer, 1896 to 1998: milestones along hierarchy of evidence from case report to Cochrane review Clarke, M. J. BMJ, Vol. 317, Issue 7167 https://doi.org/10.1136/bmj.317.7167.1246	journal	October 1998
Estrogen Receptor Status in Primary Breast Cancer: Iodine 123–labeled *cis* -11β-Methoxy-17α-iodovinyl Estradiol Scintigraphy Bennink, Roelof J.; Rijks, Leonie J.; van Tienhoven, Geertjan Radiology, Vol. 220, Issue 3 https://doi.org/10.1148/radiol.2203001639	journal	September 2001
Breast cancer: PET imaging of estrogen receptors. Mintun, M. A.; Welch, M. J.; Siegel, B. A. Radiology, Vol. 169, Issue 1 https://doi.org/10.1148/radiology.169.1.3262228	journal	October 1988
Fluoroestradiol Positron Emission Tomography Reveals Differences in Pharmacodynamics of Aromatase Inhibitors, Tamoxifen, and Fulvestrant in Patients with Metastatic Breast Cancer Linden, Hannah M.; Kurland, Brenda F.; Peterson, Lanell M. Clinical Cancer Research, Vol. 17, Issue 14 https://doi.org/10.1158/1078-0432.CCR-10-3321	journal	July 2011
Pharmacodynamic Imaging Guides Dosing of a Selective Estrogen Receptor Degrader Heidari, Pedram; Deng, Francis; Esfahani, Shadi A. Clinical Cancer Research, Vol. 21, Issue 6 https://doi.org/10.1158/1078-0432.CCR-14-1178	journal	January 2015
Longitudinal Noninvasive Imaging of Progesterone Receptor as a Predictive Biomarker of Tumor Responsiveness to Estrogen Deprivation Therapy Chan, Szeman Ruby; Fowler, Amy M.; Allen, Julie A. Clinical Cancer Research, Vol. 21, Issue 5 https://doi.org/10.1158/1078-0432.CCR-14-1715	journal	December 2014
Estrogen Receptor Binding ( ¹⁸ F-FES PET) and Glycolytic Activity ( ¹⁸ F-FDG PET) Predict Progression-Free Survival on Endocrine Therapy in Patients with ER ⁺ Breast Cancer Kurland, Brenda F.; Peterson, Lanell M.; Lee, Jean H. Clinical Cancer Research, Vol. 23, Issue 2 https://doi.org/10.1158/1078-0432.CCR-16-0362	journal	June 2016
Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer Inda, Márcia A.; Blok, Erik J.; Kuppen, Peter J. K. Molecular Cancer Therapeutics, Vol. 19, Issue 2 https://doi.org/10.1158/1535-7163.MCT-19-0318	journal	February 2020
Measuring Residual Estrogen Receptor Availability during Fulvestrant Therapy in Patients with Metastatic Breast Cancer van Kruchten, Michel; de Vries, Elisabeth G.; Glaudemans, Andor W. Cancer Discovery, Vol. 5, Issue 1 https://doi.org/10.1158/2159-8290.CD-14-0697	journal	November 2014
A Review of Endocrine Options for the Treatment of Advanced Breast Cancer Kaufmann, M. Oncology, Vol. 54, Issue 2 https://doi.org/10.1159/000227747	journal	January 1997
Imaging in breast cancer: Single-photon computed tomography and positron-emission tomography Bénard, François; Turcotte, Éric Breast Cancer Research, Vol. 7, Issue 4 https://doi.org/10.1186/bcr1201	journal	May 2005
STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas Chan, Szeman Ruby; Vermi, William; Luo, Jingqin Breast Cancer Research, Vol. 14, Issue 1 https://doi.org/10.1186/bcr3100	journal	January 2012
Effects of tissue decalcification on the quantification of breast cancer biomarkers by digital image analysis Gertych, Arkadiusz; Mohan, Sonia; Maclary, Shawn Diagnostic Pathology, Vol. 9, Issue 1 https://doi.org/10.1186/s13000-014-0213-9	journal	November 2014
Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association Tonsing-Carter, Eva; Hernandez, Kyle M.; Kim, Caroline R. Breast Cancer Research, Vol. 21, Issue 1 https://doi.org/10.1186/s13058-019-1164-6	journal	July 2019
Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression Allott, Louis; Miranda, Cecilia; Hayes, Angela EJNMMI Radiopharmacy and Chemistry, Vol. 4, Issue 1 https://doi.org/10.1186/s41181-018-0054-z	journal	January 2019
Imaging of estrogen receptors in primary and metastatic breast cancer patients with iodine-123-labeled Z-MIVE. Rijks, L. J.; Bakker, P. J.; van Tienhoven, G. Journal of Clinical Oncology, Vol. 15, Issue 7 https://doi.org/10.1200/JCO.1997.15.7.2536	journal	July 1997
Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer Harvey, Jennet M.; Clark, Gary M.; Osborne, C. Kent Journal of Clinical Oncology, Vol. 17, Issue 5 https://doi.org/10.1200/JCO.1999.17.5.1474	journal	May 1999
Metabolic Flare: Indicator of Hormone Responsiveness in Advanced Breast Cancer Mortimer, Joanne E.; Dehdashti, Farrokh; Siegel, Barry A. Journal of Clinical Oncology, Vol. 19, Issue 11 https://doi.org/10.1200/JCO.2001.19.11.2797	journal	June 2001
Prospective Study Evaluating the Impact of Tissue Confirmation of Metastatic Disease in Patients With Breast Cancer Amir, Eitan; Miller, Naomi; Geddie, William Journal of Clinical Oncology, Vol. 30, Issue 6 https://doi.org/10.1200/JCO.2010.33.5232	journal	February 2012
Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-Resistant Prostate Cancer Rathkopf, Dana E.; Morris, Michael J.; Fox, Josef J. Journal of Clinical Oncology, Vol. 31, Issue 28 https://doi.org/10.1200/JCO.2013.50.1684	journal	October 2013
Glucocorticoid and Mineralocorticoid Cross-Talk with Progesterone Receptor to Induce Focal Adhesion and Growth Inhibition in Breast Cancer Cells Leo, Joyce C. L.; Guo, Chunhua; Woon, Chow Thai Endocrinology, Vol. 145, Issue 3 https://doi.org/10.1210/en.2003-0732	journal	March 2004
E-17 α -(2-[ ¹²⁵ I]IODOVINYL)-19-NORTESTOSTERONE: THE SYNTHESIS OF A GAMMA-EMITTING LIGAND FOR THE PROGESTERONE RECEPTOR. Hochberg, Richard B.; Hoyte, Robert M.; Rosner, W. Endocrinology, Vol. 117, Issue 6 https://doi.org/10.1210/endo-117-6-2550	journal	December 1985
Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists. Kraus, W. L.; Katzenellenbogen, B. S. Endocrinology, Vol. 132, Issue 6 https://doi.org/10.1210/endo.132.6.8504742	journal	June 1993
Progesterone-Binding Proteins: in Vitro Binding and Biological Activity of Different Steroidal Ligands Kontula, Kimmo; Jänne, Olli; Vihko, Reijo Acta Endocrinologica, Vol. 78, Issue 3 https://doi.org/10.1530/acta.0.0780574	journal	March 1975
Whole‐Body Characterization of Estrogen Receptor Status in Metastatic Breast Cancer with 16α‐18F‐Fluoro‐17β‐Estradiol Positron Emission Tomography: Meta‐Analysis and Recommendations for Integration into Clinical Applications Kurland, Brenda F.; Wiggins, Jay R.; Coche, Amandine The Oncologist, Vol. 25, Issue 10 https://doi.org/10.1634/theoncologist.2019-0967	journal	May 2020
Radiolabeled Glucocorticoids as Molecular Probes for Imaging Brain Glucocorticoid Receptors by Means of Positron Emission Tomography (PET) Steiniger, Bjorn; Kniess, Torsten; Bergmann, Ralf Mini-Reviews in Medicinal Chemistry, Vol. 8, Issue 7 https://doi.org/10.2174/138955708784567403	journal	June 2008
18F-Fluoroestradiol Positron Emission Tomography in Breast Cancer Patients: Systematic Review of the Literature & Meta-Analysis Evangelista, Laura; Vittoria Dieci, Maria; Guarneri, Valentina Current Radiopharmaceuticals, Vol. 9, Issue 3 https://doi.org/10.2174/1874471009666161019144950	journal	December 2016
PET Imaging of Steroid Hormone Receptor Expression Allott, Louis; Smith, Graham; Aboagye, Eric O. Molecular Imaging, Vol. 14, Issue 10 https://doi.org/10.2310/7290.2015.00026	journal	October 2015
Pharmacokinetic Assessment of the Uptake of 16β- ¹⁸ F-Fluoro-5α-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PET Beattie, Bradley J.; Smith-Jones, Peter M.; Jhanwar, Yuliya S. Journal of Nuclear Medicine, Vol. 51, Issue 2 https://doi.org/10.2967/jnumed.109.066159	journal	January 2010
Between-Patient and Within-Patient (Site-to-Site) Variability in Estrogen Receptor Binding, Measured In Vivo by ¹⁸ F-Fluoroestradiol PET Kurland, Brenda F.; Peterson, Lanell M.; Lee, Jean H. Journal of Nuclear Medicine, Vol. 52, Issue 10 https://doi.org/10.2967/jnumed.111.091439	journal	September 2011
PET Imaging of Estrogen Receptors as a Diagnostic Tool for Breast Cancer Patients Presenting with a Clinical Dilemma van Kruchten, Michel; Glaudemans, Andor W. J. M.; de Vries, Erik F. J. Journal of Nuclear Medicine, Vol. 53, Issue 2 https://doi.org/10.2967/jnumed.111.092734	journal	January 2012
Assessment of Progesterone Receptors in Breast Carcinoma by PET with 21- ¹⁸ F-Fluoro-16α,17α-[( R )-(1′-α-furylmethylidene)Dioxy]-19-Norpregn-4-Ene-3,20-Dione Dehdashti, Farrokh; Laforest, Richard; Gao, Feng Journal of Nuclear Medicine, Vol. 53, Issue 3 https://doi.org/10.2967/jnumed.111.098319	journal	February 2012
Small-Animal PET of Steroid Hormone Receptors Predicts Tumor Response to Endocrine Therapy Using a Preclinical Model of Breast Cancer Fowler, Amy M.; Chan, Szeman Ruby; Sharp, Terry L. Journal of Nuclear Medicine, Vol. 53, Issue 7 https://doi.org/10.2967/jnumed.112.103465	journal	June 2012
Imaging Diagnostic and Therapeutic Targets: Steroid Receptors in Breast Cancer Fowler, Amy M.; Clark, Amy S.; Katzenellenbogen, John A. Journal of Nuclear Medicine, Vol. 57, Issue Supplement 1 https://doi.org/10.2967/jnumed.115.157933	journal	February 2016
¹⁸ F-Fluoroestradiol PET: Current Status and Potential Future Clinical Applications Liao, Geraldine J.; Clark, Amy S.; Schubert, Erin K. Journal of Nuclear Medicine, Vol. 57, Issue 8 https://doi.org/10.2967/jnumed.116.175596	journal	June 2016
A Randomized Feasibility Study of ¹⁸ F-Fluoroestradiol PET to Predict Pathologic Response to Neoadjuvant Therapy in Estrogen Receptor–Rich Postmenopausal Breast Cancer Chae, Sun Young; Kim, Sung-Bae; Ahn, Sei Hyun Journal of Nuclear Medicine, Vol. 58, Issue 4 https://doi.org/10.2967/jnumed.116.178368	journal	September 2016
¹⁸ F-Fluoroestradiol Tumor Uptake Is Heterogeneous and Influenced by Site of Metastasis in Breast Cancer Patients Nienhuis, Hilde H.; van Kruchten, Michel; Elias, Sjoerd G. Journal of Nuclear Medicine, Vol. 59, Issue 8 https://doi.org/10.2967/jnumed.117.198846	journal	March 2018
Sensitivity and Isoform Specificity of ¹⁸ F-Fluorofuranylnorprogesterone for Measuring Progesterone Receptor Protein Response to Estradiol Challenge in Breast Cancer Salem, Kelley; Kumar, Manoj; Yan, Yongjun Journal of Nuclear Medicine, Vol. 60, Issue 2 https://doi.org/10.2967/jnumed.118.211516	journal	July 2018
Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer Kumar, Manoj; Salem, Kelley; Tevaarwerk, Amye J. Journal of Nuclear Medicine, Vol. 61, Issue 2 https://doi.org/10.2967/jnumed.119.228858	journal	November 2019
¹⁷⁷ Lu-EB-PSMA Radioligand Therapy with Escalating Doses in Patients with Metastatic Castration-Resistant Prostate Cancer Zang, Jie; Liu, Qingxing; Sui, Huimin Journal of Nuclear Medicine, Vol. 61, Issue 12 https://doi.org/10.2967/jnumed.120.242263	journal	May 2020
Dna Damage Induction by ¹²⁵ I-Estrogen Yasui, Linda S.; Hughes, Alun; Desombre, Eugene R. Acta Oncologica, Vol. 35, Issue 7 https://doi.org/10.3109/02841869609104035	journal	January 1996
Biological Activities of 16 , 17 Dihydroxyprogesterone Derivatives Lerner, L. J.; Brennan, D. M.; Borman, A. Experimental Biology and Medicine, Vol. 106, Issue 1 https://doi.org/10.3181/00379727-106-26296	journal	January 1961
Morphologic, Molecular and Clinical Features of Aggressive Variant Prostate Cancer Montironi, Rodolfo; Cimadamore, Alessia; Lopez-Beltran, Antonio Cells, Vol. 9, Issue 5 https://doi.org/10.3390/cells9051073	journal	April 2020
Recent Advances in Prostate Cancer Treatment and Drug Discovery Nevedomskaya, Ekaterina; Baumgart, Simon; Haendler, Bernard International Journal of Molecular Sciences, Vol. 19, Issue 5 https://doi.org/10.3390/ijms19051359	journal	May 2018
Fluorine-18 Labeled Fluorofuranylnorprogesterone ([18F]FFNP) and Dihydrotestosterone ([18F]FDHT) Prepared by “Fluorination on Sep-Pak” Method Basuli, Falguni; Zhang, Xiang; Blackman, Burchelle Molecules, Vol. 24, Issue 13 https://doi.org/10.3390/molecules24132389	journal	June 2019
Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update Allison, Kimberly H.; Hammond, M. Elizabeth H.; Dowsett, Mitchell Archives of Pathology & Laboratory Medicine, Vol. 144, Issue 5 https://doi.org/10.5858/arpa.2019-0904-SA	journal	January 2020
Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression Allott, Louis; Miranda, Cecilia; Hayes, Angela Figshare https://doi.org/10.6084/m9.figshare.c.4363643	collection	January 2019
Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association Tonsing-Carter, Eva; Hernandez, Kyle; Kim, Caroline Figshare https://doi.org/10.6084/m9.figshare.c.4588790.v1	collection	January 2019
Auger radiopharmaceutical therapy targeting prostate-specific membrane antigen in a micrometastatic model of prostate cancer Shen, Colette J.; Minn, Il; Hobbs, Robert F. Theranostics, Vol. 10, Issue 7 https://doi.org/10.7150/thno.38882	journal	January 2020

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60 APPLIED LIFE SCIENCES
FDHT
FES
FFNP
Oncology
PET imaging
breast cancer
endocrine therapy
hormone-challenge test
prostate cancer
radiopharmaceuticals
receptor-targeting

PET Imaging Agents (FES, FFNP, and FDHT) for Estrogen, Androgen, and Progesterone Receptors to Improve Management of Breast and Prostate Cancers by Functional Imaging

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