(Fluorine-18 labeled androgens and progestins; imaging agents for tumors of prostate and breast): Technical progress report, February 1, 1987-January 31, 1988

Technical Report · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5963310

Katzenellenbogen, J A

This project develops fluorine-18 labeled steroids that possess high binding affinity and selectivity for androgen and progesterone receptors and can be used as positron-emission tomographic imaging agents for prostate tumors and breast tumors, respectively. These novel diagnostic agents may enable an accurate estimation of tumor dissemination, such as metastasis of prostate cancer and lymph node involvement of breast cancer, and an in vivo determination of the endocrine responsiveness of these tumors. They will provide essential information for the selection of alternative therapies thereby improving the management of prostate and breast cancer patients. 14 refs., 1 tab.

• Research Organization: Illinois Univ., Urbana (USA)
• DOE Contract Number: FG02-86ER60401
• OSTI ID: 5963310
• Report Number(s): DOE/ER/60401-18; ON: DE88000808
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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62 RADIOLOGY AND NUCLEAR MEDICINE
ADIPOSE TISSUE
ANDROGENS
ANDROSTANES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
CONNECTIVE TISSUE
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOCUMENT TYPES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ESTROGENS
FEMALE GENITALS
FLUORINE 18
FLUORINE ISOTOPES
GLANDS
GONADS
HORMONES
HOURS LIVING RADIOISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
LIVER
MALE GENITALS
MAMMALS
MAMMARY GLANDS
MATERIALS
MUSCLES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OVARIES
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
PROSTATE
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SAMPLE PREPARATION
SKELETON
STEROID HORMONES
STEROIDS
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TISSUE DISTRIBUTION
TISSUES
TOMOGRAPHY
UTERUS
VERTEBRATES