Prevention and reversal by a retinoid of 3,4-benzpyrene- and cigarette smoke condensate-induced hyperplasia and metaplasia of rodent respiratory epithelia in organ culture

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · Cancer Treat. Rep.; (United States)

OSTI ID:6702424

Lasnitzki, I; Bollag, W

The influence of an aromatic analog of vitamin A, etretinate, on the effects of 3,4-benzpyrene and cigarette smoke condensate has been investigated in fetal mouse lung and neonatal rat tracheas grown in organ culture. In both tissues, 3,4-benzpyrene as well as cigarette smoke condensate induces a striking increase of epithelial mitosis within 12--14 days of treatment. The increase is associated with a loss of secretory activity and of ciliary function. These changes persist in the absence of benzpyrene or smoke condensate in explants transferred to control medium. Treatment with etretinate alone does not affect the normal epithelial growth rate or normal differentiation. If combined with either benzpyrene or smoke condensate, the aromatic compound inhibits the increase in cell division and prevents the loss of secretory activity or ciliary function. In explants pretreated with 3,4-benzpyrene or cigarette smoke condensate, etretinate reduces the carcinogen- or smoke condensate-induced increase in mitotic activity to normal levels and restores secretory differentiation and ciliary function. The mechanism of action involved in the anticarcinogenic activity of the retinoid is discussed.

• Research Organization: Department of Pharmaceutical Research, F. Hoffmann-La Roche and Co, Ltd, Basel, Switzerland
• OSTI ID: 6702424
• Journal Information: Cancer Treat. Rep.; (United States), Journal Name: Cancer Treat. Rep.; (United States) Vol. 66:6; ISSN CTRRD
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
550400 -- Genetics
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CELL DIVISION
COLLOIDS
CONDENSED AROMATICS
DISPERSIONS
EPITHELIUM
GENETIC EFFECTS
HYDROCARBONS
LUNGS
MAMMALS
MICE
MITOSIS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
TISSUE CULTURES
TISSUES
TOBACCO SMOKES
VERTEBRATES