Tolerance of previously irradiated mouse kidneys to cis-diamminedichloroplatinum(II)

Journal Article · Sun Feb 15 04:00:00 EST 1987 · Cancer Res.; (United States)

OSTI ID:6700461

Stewart, F A; Luts, A; Begg, A C

In this study the tolerance of previously irradiated kidneys to retreatment with chemotherapy was assessed. cis-Diamminedichloroplatinum(II) (c-DDP) was given to groups of mice at 1, 3, or 6 months after bilateral renal irradiation with single doses of 8-14 Gy. Renal function was measured monthly (by clearance of 51Cr ethylenediaminetetraacetic acid) from 4-35 weeks after c-DDP injection and results were compared with function after X-rays alone or drug alone. At early testing times (during the first 11 weeks after c-DDP injection) the renal function of mice given drug at 1 or 3 months after irradiation was very similar to that seen after drug alone. c-DDP given at 6 months caused slightly more damage than either drug or X-rays alone, but these results could be explained in terms of additive toxicities. At later testing times (11-35 weeks after c-DDP injection), renal function was much worse in all animals which had received previous irradiation, with the greatest damage when c-DDP was given 6 months after X-rays. This may be partly due to additional cell killing by the drug causing the expression of subclinical radiation injury. It is also possible that c-DDP pharmacokinetics was altered in animals with previously irradiated kidneys, leading to higher drug exposures in these mice.

• Research Organization: Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam
• OSTI ID: 6700461
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 4; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM 51
CHROMIUM ISOTOPES
CLEARANCE
EDTA
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOTOPES
KIDNEYS
MAMMALS
METALS
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PLATINUM
PLATINUM METALS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RENAL CLEARANCE
RODENTS
TOLERANCE
TRANSITION ELEMENTS
VERTEBRATES
X RADIATION